[HTML][HTML] Anticancer alkaloids from trees: Development into drugs

T Isah - Pharmacognosy reviews, 2016 - ncbi.nlm.nih.gov
Trees have made an enormous phytochemical contribution in anticancer drugs'
development more than any other life form. The contributions include alkaloids that are …

Progress of the synthesis of condensed pyrazole derivatives (from 2010 to mid-2013)

M Li, BX Zhao - European Journal of Medicinal Chemistry, 2014 - Elsevier
Condensed pyrazole derivatives are important heterocyclic compounds due to their
excellent biological activities and have been widely applied in pharmaceutical and …

Synthesis, spectroscopic characterization (FT-IR, NMR) and DFT computational studies of new isoxazoline derived from acridone

M Aarjane, S Slassi, A Ghaleb, A Amine - Journal of Molecular Structure, 2021 - Elsevier
In this study, a new isoxazoline derived from acridone, 10‐{[3‐(4‐chlorophenyl)‐4, 5‐
dihydro‐1, 2‐oxazol‐5 yl] methyl} acridone (3) was successfully synthesized and …

Synthesis and anticancer properties of functionalized 1, 6-naphthyridines

M Lavanya, C Lin, J Mao, D Thirumalai… - Topics in Current …, 2021 - Springer
The burgeoning interest in synthesis and biological applications of 1, 6-naphthyridines
reflects the importance of 1, 6-naphthyridines in the synthetic as well as medicinal chemistry …

Synthesis and antiviral activity of new 4-(phenylamino)/4-[(methylpyridin-2-yl)amino]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acids derivatives

AMR Bernardino, AR de Azevedo, LCS Pinheiro… - Medicinal Chemistry …, 2007 - Springer
The synthesis of new 4-(phenylamino)-1-phenyl-1 H-pyrazolo [3, 4-b] pyridine-4-carboxylic
acid (3a-l) derivatives and the new 4-[(methylpyridin-2-yl) amino]-1-phenyl-1 H-pyrazolo [3 …

Copper-free Sonogashira coupling of 2-chloroquinolines with phenyl acetylene and quick annulation to benzo [b][1, 6] naphthyridine derivatives in aqueous ammonia

A Chandra, B Singh, S Upadhyay, RM Singh - Tetrahedron, 2008 - Elsevier
An efficient copper-free Sonogashira coupling of 2-chloroquinolines with phenyl acetylene
to 2-ethynylquinolines is described. We further discussed the one pot facile annulation of 2 …

New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection

A Stankiewicz-Drogon, LG Palchykovska… - Bioorganic & medicinal …, 2008 - Elsevier
A new class of compounds—acridone derivatives—was tested using the direct fluorometric
helicase activity assay to determine the inhibitory properties of the derivatives towards the …

Structural characterization, thermal investigation and biological activity of metal complexes containing Schiff Base ligand (Z)‐3‐(1‐((4, 6‐dimethyl‐1H‐pyrazolo [3, 4‐b …

SM Emam, SA Abouel‐Enein… - Applied …, 2019 - Wiley Online Library
A new series of metal complexes containing Co (II), Pd (II), Fe (III) chloride and Cu (II) salts
(chloride, bromide, sulphate and perchlorate) have been prepared with Schiff base ligand …

Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure–activity relationship studies of 1H-pyrazolo [3, 4-b] pyridine and …

B Leal, IF Afonso, CR Rodrigues, PA Abreu… - Bioorganic & medicinal …, 2008 - Elsevier
Antibacterial resistance is a complex problem that contributes to health and economic losses
worldwide. The Staphylococcus epidermidis is an important nosocomial pathogen that …

HSV-1 Glycoprotein D and Its Surface Receptors: Evaluation of Protein–Protein Interaction and Targeting by Triazole-Based Compounds through In Silico Approaches

R Bivacqua, I Romeo, M Barreca, P Barraja… - International Journal of …, 2023 - mdpi.com
Protein–protein interactions (PPI) represent attractive targets for drug design. Thus, aiming
at a deeper insight into the HSV-1 envelope glycoprotein D (gD), protein–protein docking …