The primary cilium is an organelle which consists of a microtubule in the core and a
surrounding cilia membrane, and has long been recognized as a “vestigial organelle” …

The aberrant expression of Wnt3 has linked to several types of human malignancies.
However, it is not known for its role in tumorigenesis of colorectal cancer (CRC). Herein, we …

Background A transient increase in cytosolic Ca 2+(the “Ca 2+ transient”) determines the
degree and duration of myocyte force development in the heart. However, we have …

Periodic patterning of iterative structures is a fundamental process during embryonic
development, since these structures are diverse across the animal kingdom. Therefore …

Prostate cancer (PCa) and breast cancer (BC) present formidable challenges in global
cancer-related mortality, necessitating effective management strategies. The present study …

Meckel-Gruber syndrome (MKS) and Joubert syndrome (JBTS) are rare autosomal
recessive genetic disorders caused by genetic defects in proteins responsible for primary …

Diverticular disease (DD) is a multistage gastrointestinal disorder of the colon. DD begins
with colonic outpouching, creating diverticula. This stage of disease is called diverticulosis …

Shear stress regulated signaling in renal epithelial cells and polycystic kidney disease Cover
Page The handle http://hdl. handle. net/1887/66002 holds various files of this Leiden University …

The kidney is a uniquely shaped organ that our body requires to maintain fluid homeostasis.
Its formation begins with a mesenchymal to epithelial transition, where epithelial branching …

Abstract Planar Cell Polarity (PCP) has emerged as an important pathway in organ
development and tissue morphogenesis. PCP is responsible for the downstream cascades …