Omics-based strategies in precision medicine: toward a paradigm shift in inborn errors of metabolism investigations

A Tebani, C Afonso, S Marret, S Bekri - International journal of molecular …, 2016 - mdpi.com
The rise of technologies that simultaneously measure thousands of data points represents
the heart of systems biology. These technologies have had a huge impact on the discovery …

A review of metabolomics approaches and their application in identifying causal pathways of childhood asthma

KN Turi, L Romick-Rosendale, KK Ryckman… - Journal of Allergy and …, 2018 - Elsevier
Because asthma is a disease that results from host-environment interactions, an approach
that allows assessment of the effect of the environment on the host is needed to understand …

COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms

M Ostaszewski, A Niarakis, A Mazein… - Molecular systems …, 2021 - embopress.org
We need to effectively combine the knowledge from surging literature with complex datasets
to propose mechanistic models of SARS‐CoV‐2 infection, improving data interpretation and …

Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms

A Mazein, M Ostaszewski, I Kuperstein… - NPJ systems biology …, 2018 - nature.com
The development of computational approaches in systems biology has reached a state of
maturity that allows their transition to systems medicine. Despite this progress, intuitive …

FAIRification of health-related data using semantic web technologies in the Swiss Personalized Health Network

V Touré, P Krauss, K Gnodtke, J Buchhorn, D Unni… - Scientific Data, 2023 - nature.com
Abstract The Swiss Personalized Health Network (SPHN) is a government-funded initiative
developing federated infrastructures for a responsible and efficient secondary use of health …

Review of statistical learning methods in integrated omics studies (an integrated information science)

ISL Zeng, T Lumley - Bioinformatics and biology insights, 2018 - journals.sagepub.com
Integrated omics is becoming a new channel for investigating the complex molecular system
in modern biological science and sets a foundation for systematic learning for precision …

Community-driven roadmap for integrated disease maps

M Ostaszewski, S Gebel, I Kuperstein… - Briefings in …, 2019 - academic.oup.com
Abstract The Disease Maps Project builds on a network of scientific and clinical groups that
exchange best practices, share information and develop systems biomedicine tools. The …

-Omics biomarker identification pipeline for translational medicine

L Bravo-Merodio, JA Williams, GV Gkoutos… - Journal of translational …, 2019 - Springer
Background Translational medicine (TM) is an emerging domain that aims to facilitate
medical or biological advances efficiently from the scientist to the clinician. Central to the TM …

Analysis and visualization implementation of medical big data resource sharing mechanism based on deep learning

Y Yang, T Chen - IEEE Access, 2019 - ieeexplore.ieee.org
With the development of information technology, the informationization of the medical
industry is also constantly developing rapidly, and medical data is growing exponentially. In …

What did we learn from multiple omics studies in asthma?

O Ivanova, LB Richards, SJ Vijverberg, AH Neerincx… - Allergy, 2019 - Wiley Online Library
More than a decade has passed since the finalization of the Human Genome Project. Omics
technologies made a huge leap from trendy and very expensive to routinely executed and …