The next-generation DNA vaccine platforms and delivery systems: Advances, challenges and prospects

B Lu, JM Lim, B Yu, S Song, P Neeli… - Frontiers in …, 2024 - frontiersin.org
Vaccines have proven effective in the treatment and prevention of numerous diseases.
However, traditional attenuated and inactivated vaccines suffer from certain drawbacks such …

[HTML][HTML] Antibiotic resistant bacteria in food systems: Current status, resistance mechanisms, and mitigation strategies

SA Okaiyeto, PP Sutar, C Chen, JB Ni, J Wang… - Agriculture …, 2024 - Elsevier
The pervasive use of antibiotics in agriculture and animal husbandry has raised a significant
concern—residual antibiotic contamination in food, which contributes to the natural evolution …

Carrier diversity and chemical ligations in the toolbox for designing tumor-associated carbohydrate antigens (TACAs) as synthetic vaccine candidates

R Roy, L Mousavifar - Chemical Society Reviews, 2023 - pubs.rsc.org
This review highlights the recent development in the use of carriers of increasing simplicities
and versatile chemical ligation processes leading to synthetic vaccine candidates against …

Virus-based biological systems as next-generation carriers for the therapy of central nervous system diseases

I Nowak, M Madej, J Secemska, R Sarna… - Pharmaceutics, 2023 - mdpi.com
Central nervous system (CNS) diseases are currently a major challenge in medicine. One
reason is the presence of the blood–brain barrier, which is a significant limitation for …

The bacterial spore as a mucosal vaccine delivery system

A Saggese, L Baccigalupi, G Donadio, E Ricca… - International Journal of …, 2023 - mdpi.com
The development of efficient mucosal vaccines is strongly dependent on the use of
appropriate vectors. Various biological systems or synthetic nanoparticles have been …

[HTML][HTML] Retinal organoid and gene editing for basic and translational research

YM Cheng, C Ma, K Jin, ZB Jin - Vision Research, 2023 - Elsevier
The rapid evolution of two technologies has greatly transformed the basic, translational, and
clinical research in the mammalian retina. One is the retinal organoid (RO) technology …

mRNA therapies: Pioneering a new era in rare genetic disease treatment

G Shen, J Liu, H Yang, N Xie, Y Yang - Journal of Controlled Release, 2024 - Elsevier
Rare genetic diseases, often referred to as orphan diseases due to their low prevalence and
limited treatment options, have long posed significant challenges to our medical system. In …

Living virus‐based nanohybrids for biomedical applications

L Jin, Z Mao - Wiley Interdisciplinary Reviews: Nanomedicine …, 2024 - Wiley Online Library
Living viruses characterized by distinctive biological functions including specific targeting,
gene invasion, immune modulation, and so forth have been receiving intensive attention …

Protein-based nanoparticles for therapeutic nucleic acid delivery

F Eweje, ML Walsh, K Ahmad, V Ibrahim, A Alrefai… - Biomaterials, 2024 - Elsevier
To realize the full potential of emerging nucleic acid therapies, there is a need for effective
delivery agents to transport cargo to cells of interest. Protein materials exhibit several unique …

Selective extraction of recombinant membrane proteins from Hansenula polymorpha by pulsed electric field and lytic enzyme pretreatment

V Ganeva, A Kranz - Microbial Cell Factories, 2023 - Springer
Background In yeast, recombinant membrane proteins including viral scaffold proteins used
for the formation of enveloped Virus-like particles (eVLPs) typically accumulate …