IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Abstract IL-17-producing T helper (Th17) cells have been implicated in the pathogenesis of
many inflammatory and autoimmune diseases. Targeting the effector cytokines IL-17 and …

Immune checkpoint blockade (ICB) therapy frequently induces immune-related adverse
events. To elucidate the underlying immunobiology, we performed a deep immune analysis …

Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic,
particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …

The balance between Th17 cells and regulatory T cells (Tregs) has emerged as a prominent
factor in regulating autoimmunity and cancer. Th17 cells are vital for host defense against …

Since the original identification of the T helper 17 (Th17) subset in 2005, it has become
evident that these cells do not only contribute to host defence against pathogens, such as …

Immune checkpoint inhibitors are associated with immune-related adverse events (irAEs),
including arthritis (arthritis-irAE). Management of arthritis-irAE is challenging because …

The synovium is the major target tissue of inflammatory arthritides such as rheumatoid
arthritis. The study of synovial tissue has advanced considerably throughout the past few …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a
growth factor that induces the differentiation and proliferation of myeloid progenitors in the …