Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …

Agmatine, the decarboxylation product of arginine, was largely neglected as an important
player in mammalian metabolism until the mid-1990s, when it was re-discovered as an …

Neuropeptide Y (NPY), a neuropeptide highly conserved throughout evolution, is present at
high levels in the central nervous system (CNS), as well as in peripheral tissues such as the …

Previous studies have suggested that neuropeptide Y (NPY) levels may be altered in
patients with major depressive disorder (MDD), post‐traumatic stress disorder (PTSD) and …

Agmatine is a neuromodulator that regulates multiple neurotransmitters and signaling
pathways. Several studies have focused on elucidating the mechanisms underlying the …

Major depressive disorder is the most common psychiatric disorder with lifetime prevalence
of up to 20% worldwide. It is responsible for more years lost to disability than any other …

We investigated the involvement of neuropeptide Y (NPY) in the modulation of
cholecystokinin-4 (CCK-4)-evoked anxiety and depression. Adult male mice were injected …

Premenstrual dysphoric disorder (PMDD) is characterized by various physical and affective
symptoms, including anxiety, irritability, anhedonia, social withdrawal, and depression. The …

A need for new antidepressants is necessary since traditional antidepressants have several
flaws. Neuropeptide Y (NPY) Y1 receptor (NPYY1R) and galanin (GAL) receptor 2 (GALR2) …

Delivery of neuropeptide Y (NPY) to the brain by intranasal infusion soon after traumatic
stress has shown therapeutic potential, and prevented development of many behavioral and …