The role of bile acids in carcinogenesis
Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …
Bile acids and their receptors in metabolic disorders
Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …
[HTML][HTML] The bile acid TGR5 membrane receptor: from basic research to clinical application
H Duboc, Y Taché, AF Hofmann - Digestive and Liver Disease, 2014 - Elsevier
The TGR5 receptor (or GP-BAR1, or M-BAR) was characterized ten years ago as the first
identified G-coupled protein receptor specific for bile acids. TGR5 gene expression is widely …
identified G-coupled protein receptor specific for bile acids. TGR5 gene expression is widely …
Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites
Objective Cigarette smoking is a major risk factor for colorectal cancer (CRC). We aimed to
investigate whether cigarette smoke promotes CRC by altering the gut microbiota and …
investigate whether cigarette smoke promotes CRC by altering the gut microbiota and …
TGR5, not only a metabolic regulator
C Guo, WD Chen, YD Wang - Frontiers in physiology, 2016 - frontiersin.org
G-protein-coupled bile acid receptor, Gpbar1 (TGR5), is a member of G-protein-coupled
receptor (GPCR) superfamily. High levels of TGR5 mRNA were detected in several tissues …
receptor (GPCR) superfamily. High levels of TGR5 mRNA were detected in several tissues …
The biosynthesis, signaling, and neurological functions of bile acids
Y Kiriyama, H Nochi - Biomolecules, 2019 - mdpi.com
Bile acids (BA) are amphipathic steroid acids synthesized from cholesterol in the liver. They
act as detergents to expedite the digestion and absorption of dietary lipids and lipophilic …
act as detergents to expedite the digestion and absorption of dietary lipids and lipophilic …
Circulating bile acids as a link between the gut microbiota and cardiovascular health: impact of prebiotics, probiotics and polyphenol-rich foods
RAG Pushpass, S Alzoufairi, KG Jackson… - Nutrition Research …, 2022 - cambridge.org
Beneficial effects of probiotic, prebiotic and polyphenol-rich interventions on fasting lipid
profiles have been reported, with changes in the gut microbiota composition believed to play …
profiles have been reported, with changes in the gut microbiota composition believed to play …
Anticancer steroids: linking natural and semi-synthetic compounds
JAR Salvador, JFS Carvalho, MAC Neves… - Natural product …, 2013 - pubs.rsc.org
Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …
in animals, plants and fungi, have shown great therapeutic value for a broad array of …
TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro
M Reich, K Deutschmann, A Sommerfeld, C Klindt… - Gut, 2016 - gut.bmj.com
Objective Cholestatic liver diseases in humans as well as bile acid (BA)-feeding and
common bile duct ligation (CBDL) in rodents trigger hyperplasia of cholangiocytes within the …
common bile duct ligation (CBDL) in rodents trigger hyperplasia of cholangiocytes within the …
Bile acids in the colon, from healthy to cytotoxic molecules
Bile acids are natural detergents mainly involved in facilitating the absorption of dietary fat in
the intestine. In addition to this absorptive function, bile acids are also essential in the …
the intestine. In addition to this absorptive function, bile acids are also essential in the …