Angiogenesis is a process associated with the migration and proliferation of endothelial
cells (EC) to form new blood vessels. It is involved in various physiological and …

The urokinase‐type plasminogen activator (u‐PA) system consists of the serine proteinases
plasmin and u‐PA; the serpin inhibitors α2‐anti‐plasmin, PAI‐1 and PAI‐2; and the u‐PA …

Generation of the serine proteinase plasmin from the extracellular zymogen plasminogen
can be catalyzed by either of two other serine proteinases, the urokinase-and tissue-type …

The paradoxical pro-tumorigenic function of plasminogen activator inhibitor 1 (PAI-1, aka
Serpin E1) in cancer progression and metastasis has been the subject of an abundant …

Despite its function as an inhibitor of urokinase and tissue-type plasminogen activator (PA),
PA inhibitor-1 (PAI-1) has a paradoxical protumorigenic role in cancer, promoting …

Cellular migration is critically dependent on an interplay between forces of attachment and
detachment. Recent studies show that the serine protease urokinase and its major inhibitor …

Elevated expression of plasminogen activator inhibitor-1 (PAI-1) in tumors is associated with
a poor prognosis in many cancers. Reduced tumor growth and angiogenesis have also …

ABSTRACT Plasminogen activator inhibitor 1 (PAI‐1) is believed to control proteolytic
activity and cell migration during angiogenesis. We previously demonstrated in vivo that this …

Summary Plasminogen activator inhibitor‐1 (PAI‐1, also known as SERPINE 1) is a member
of the serine protease inhibitor (SERPIN) superfamily and is the primary physiological …

In vivo tumor progression in mice with targeted deficiencies in urokinase-type plasminogen
activator (UPA−/−) and its inhibitor, plasminogen activator inhibitor-1 (PAI-1−/−), was studied …