Adult humans fail to regenerate their hearts following injury, and this failure to regenerate
myocardium is a leading cause of heart failure and death worldwide. Although all adult …

Myocardial infarction (MI) in humans is a common cause of cardiac injury and results in
irreversible loss of myocardial cells and formation of fibrotic scar tissue. This fibrotic tissue …

Background/Aims: Cardiac fibrosis after myocardial infarction (MI) has been identified as an
important factor in the deterioration of heart function. Previous studies have demonstrated …

Mammalian cardiomyocytes become post-mitotic shortly after birth. Understanding how this
occurs is highly relevant to cardiac regenerative therapy. Yet, how cardiomyocytes achieve …

The newt and the zebrafish have the ability to regenerate many of their tissues and organs
including the heart. Thus, a major goal in experimental medicine is to elucidate the …

An innovative approach for cardiac regeneration following injury is to induce endogenous
cardiomyocyte (CM) cell cycle re-entry. In the present study, CMs from adult rat hearts were …

The mammalian heart switches its main metabolic substrate from glucose to fatty acids
shortly after birth. This metabolic switch coincides with the loss of regenerative capacity in …

Myocardial infarction (MI), caused by coronary heart disease (CHD), remains one of the
most common causes of death in the United States. Over the last few decades, scientists …

Background: Defining conserved molecular pathways in animal models of successful
cardiac regeneration could yield insight into why adult mammals have inadequate cardiac …

Despite therapeutic advances, heart failure is the major cause of morbidity and mortality
worldwide, but why cardiac regenerative capacity is lost in adult humans remains an …