Singlet molecular oxygen reactions with nucleic acids, lipids, and proteins

P Di Mascio, GR Martinez, S Miyamoto… - Chemical …, 2019 - ACS Publications
Singlet oxygen (1O2) is a biologically relevant reactive oxygen species capable of efficiently
reacting with cellular constituents. The resulting oxidatively generated damage to nucleic …

Singlet oxygen, photodynamic therapy, and mechanisms of cancer cell death

PS Maharjan, HK Bhattarai - Journal of oncology, 2022 - Wiley Online Library
Photodynamic therapy (PDT) can be developed into an important arsenal against cancer; it
is a minimally invasive therapy, which is used in the treatment or/and palliation of a variety of …

Singlet oxygen-mediated damage to proteins and its consequences

MJ Davies - Biochemical and biophysical research communications, 2003 - Elsevier
Proteins comprise approximately 68% of the dry weight of cells and tissues and are
therefore potentially major targets for oxidative damage. Two major types of processes can …

Cold atmospheric plasma and plasma-activated medium trigger RONS-based tumor cell apoptosis

G Bauer, D Sersenová, DB Graves, Z Machala - Scientific reports, 2019 - nature.com
The selective in vitro anti-tumor mechanisms of cold atmospheric plasma (CAP) and plasma-
activated media (PAM) follow a sequential multi-step process. The first step involves the …

Antioxidant characterization: methodology and mechanism

B Halliwell - Biochemical pharmacology, 1995 - Elsevier
The word “antioxidant” means different things to different people. Often (eg by food
scientists) the term is implicitly restricted to chain-breaking inhibitors of lipid peroxidation …

[HTML][HTML] The synergistic effect between hydrogen peroxide and nitrite, two long-lived molecular species from cold atmospheric plasma, triggers tumor cells to induce …

G Bauer - Redox biology, 2019 - Elsevier
Nitrite and H 2 O 2 are long-lived species in cold atmospheric plasma and plasma-activated
medium. It is known that their synergistic interaction is required for selective apoptosis …

Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence

RJ Reiter, D Tan, LC Manchester, W Qi - Cell biochemistry and biophysics, 2001 - Springer
Abstract Melatonin (N-acetyl-5-methoxytryptamine), an endogenously produced indole
found throughout the animal kingdom, was recently reported, using a variety of techniques …

Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide

ES Henle, S Linn - Journal of Biological Chemistry, 1997 - ASBMB
Although oxygen is a powerful oxidant, the triplet ground state of dioxygen constitutes a
kinetic barrier for oxidation of biological molecules, which are mostly singlet state (1) …

The role of catalases in the prevention/promotion of oxidative stress

L Gebicka, J Krych-Madej - Journal of inorganic biochemistry, 2019 - Elsevier
Catalases, heme enzymes which catalyze decomposition of hydrogen peroxide to water and
molecular oxygen, are important members of the antioxidant defense system of cells of …

Reactive species formed on proteins exposed to singlet oxygen

MJ Davies - Photochemical & Photobiological Sciences, 2004 - Springer
Abstract Singlet oxygen (1 O 2) is believed to be generated in biological systems by a range
of endogenous processes (eg. enzymatic and chemical reactions) and exogenous stimuli …