Biosynthesis of DNA-alkylating antitumor natural products
DNA-alkylating natural products play an important role in drug development due to their
significant antitumor activities. They usually show high affinity with DNA through different …
significant antitumor activities. They usually show high affinity with DNA through different …
An interstrand DNA crosslink glycosylase aids Acinetobacter baumannii pathogenesis
Maintenance of DNA integrity is essential to all forms of life. DNA damage generated by
reaction with genotoxic chemicals results in deleterious mutations, genome instability, and …
reaction with genotoxic chemicals results in deleterious mutations, genome instability, and …
Yatakemycin biosynthesis requires two deoxyribonucleases for toxin self-resistance
J Dorival, H Yuan, AS Walker, GL Tang… - RSC Chemical …, 2025 - pubs.rsc.org
The highly active natural product yatakemycin (YTM) from Streptomyces sp. TP-A0356 is a
potent DNA damaging agent with antimicrobial and antitumor properties. The YTM …
potent DNA damaging agent with antimicrobial and antitumor properties. The YTM …
Characterization of Bacterial DNA Glycosylases Involved in Interstrand Crosslink Repair and Antibiotic Resistance
NP Bradley - 2022 - search.proquest.com
DNA is a fundamental biomolecule of life which stores the genetic information of organisms
and drives many of the evolutionary processes in nature. Despite this, DNA is subject to …
and drives many of the evolutionary processes in nature. Despite this, DNA is subject to …