The promise of organ and tissue preservation to transform medicine
The ability to replace organs and tissues on demand could save or improve millions of lives
each year globally and create public health benefits on par with curing cancer. Unmet needs …
each year globally and create public health benefits on par with curing cancer. Unmet needs …
Regulation of hypometabolism: insights into epigenetic controls
KB Storey - Journal of Experimental Biology, 2015 - journals.biologists.com
For many animals, survival of severe environmental stress (eg to extremes of heat or cold,
drought, oxygen limitation, food deprivation) is aided by entry into a hypometabolic state …
drought, oxygen limitation, food deprivation) is aided by entry into a hypometabolic state …
Therapeutic hypothermia alters microRNA responses to traumatic brain injury in rats
JS Truettner, OF Alonso, HM Bramlett… - Journal of Cerebral …, 2011 - journals.sagepub.com
Therapeutic hypothermia promotes protection after traumatic brain injury (TBI). The
mechanisms underlying hypothermic protection are multifactorial and may include the …
mechanisms underlying hypothermic protection are multifactorial and may include the …
Insight into post-transcriptional gene regulation: stress-responsive microRNAs and their role in the environmental stress survival of tolerant animals
Living animals are constantly faced with various environmental stresses that challenge
normal life, including: oxygen limitation, very low or high temperature, as well as restriction …
normal life, including: oxygen limitation, very low or high temperature, as well as restriction …
Functional impact of microRNA regulation in models of extreme stress adaptation
When confronted with severe environmental stress, some animals are able to undergo a
substantial reorganization of their cellular environment that enables long-term survival. One …
substantial reorganization of their cellular environment that enables long-term survival. One …
High-throughput sequencing reveals differential expression of miRNAs in intestine from sea cucumber during aestivation
The regulatory role of miRNA in gene expression is an emerging hot new topic in the control
of hypometabolism. Sea cucumber aestivation is a complicated physiological process that …
of hypometabolism. Sea cucumber aestivation is a complicated physiological process that …
Global protein conjugation by ubiquitin-like-modifiers during ischemic stress is regulated by microRNAs and confers robust tolerance to ischemia
Y Lee, KR Johnson, JM Hallenbeck - 2012 - journals.plos.org
Hibernation torpor provides an excellent model of natural tolerance to ischemia. We have
previously shown that massive global SUMOylation occurs during hibernation torpor in …
previously shown that massive global SUMOylation occurs during hibernation torpor in …
Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance
An important disease among human metabolic disorders is type 2 diabetes mellitus. This
disorder involves multiple physiological defects that result from high blood glucose content …
disorder involves multiple physiological defects that result from high blood glucose content …
Identification of microRNAs involved in cold adaptation of Litopenaeus vannamei by high-throughput sequencing
P He, P Wei, B Zhang, Y Zhao, Q Li, X Chen, D Zeng… - Gene, 2018 - Elsevier
The Litopenaeus vannamei (L. vannamei) is one of the most widely cultured shrimp species
in the world, with low temperature being one of the most serious threats to its growth and …
in the world, with low temperature being one of the most serious threats to its growth and …
Transcriptional evidence for small RNA regulation of pupal diapause in the flesh fly, Sarcophaga bullata
JA Reynolds, J Clark, SJ Diakoff… - Insect Biochemistry and …, 2013 - Elsevier
Understanding the molecular basis of diapause, a phenotypically plastic, alternative
developmental pathway, is key to predicting the seasonal distribution of economically and …
developmental pathway, is key to predicting the seasonal distribution of economically and …