Reactive Oxygen Species are involved in the pathological development of many important
human diseases such as neurodegenerative diseases, cardiovascular processes, diabetes …

The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case of …

Introduction: Terpenoids constitute the largest class of natural products and are a rich
reservoir of candidate compounds for drug discovery. Recent efforts into the research and …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

Osteosarcoma is the most common primary malignant tumor of bone, the long-term survival
of which has stagnated in the past several decades. Celastrol, a triterpene from traditional …

Identification of active constituents and their molecular targets from traditional medicine is an
enormous opportunity for modern pharmacology. Celastrol is one such compound that was …

The mechanism of cardiovascular diseases (CVDs) is complex and threatens human health.
Cardiomyocyte death is an important participant in the pathophysiological basis of CVDs …

The NF-κB pathway plays an important role in chronic inflammatory and autoimmune
diseases. Recently, NF-κB has also been suggested as an important mechanism linking …

Background Pancreatic cancer is one of the most serious and lethal human cancers with a
snowballing incidence around the world. The natural product celastrol has also been widely …

Cardiovascular diseases (CVD) are leading causes of morbidity and mortality worldwide;
therefore, seeking effective therapeutics to reduce the global burden of CVD has become …