Proteins carrying a signal peptide and/or a transmembrane domain enter the intracellular
secretory pathway at the endoplasmic reticulum (ER) and are transported to the Golgi …

During evolution, gene duplications lead to a naturally increased gene dosage. Duplicated
genes can be further retained or eliminated over time by purifying selection pressure. The …

Most proteins destined for the extracellular space or various intracellular compartments must
traverse the intracellular secretory pathway. The first step is the recruitment and transport of …

The oviduct is a dynamic reproductive organ for mammalian reproduction and is required for
gamete storage, maturation, fertilization, and early embryonic development, and it directly …

I am profoundly honored to have been selected to deliver the 2024 Kober Lecture of the
Association of American Physicians (AAP). I attended my first ASCI/AAP meeting (then the …

Genetics of hemostasis: from bedside to bench and back again - PMC Skip to main content
Here's how you know Official websites use .gov A .gov website belongs to an official government …

Protein secretion into the extracellular space is a fundamental process in all eukaryotic cells.
In multicellular organisms, secreted proteins participate in critical processes such as …

Antibodies play an essential role in the humoral component of the immune system. They are
produced by Antibody Secreting Cells (ASCs) which are capable of secreting thousands of …