Potassium channels (KCN) are transmembrane complexes that regulate the resting
membrane potential and the duration of action potentials in cells. The opening of KCN …

Genetic early-onset Parkinsonism is unique due to frequent co-occurrence of hyperkinetic
movement disorder (s)(MD), or additional neurological of systemic findings, including …

Sotos syndrome (SS), the most common overgrowth with intellectual disability (OGID)
disorder, is caused by inactivating germline mutations of NSD1, which encodes a histone H3 …

KCND3 encodes the voltage-gated potassium channel KV4. 3 that is highly expressed in the
cerebellum, where it regulates dendritic excitability and calcium influx. Loss-of-function KV4 …

Wenchang chicken, a prized local breed in Hainan Province of China renowned for its
exceptional adaptability to tropical environments and good meat quality, is deeply favored …

Atherogenesis and dyslipidemia increase the risk of cardiovascular disease, which is the
leading cause of death in developed countries. While blood lipid levels have been studied …

Spinocerebellar ataxia 19/22 (SCA19/22) is a rare neurodegenerative disorder caused by
mutations of the KCND3 gene, which encodes the Kv4. 3 protein. Currently, only 22 KCND3 …

TMEM175 (transmembrane protein 175) coding sequence variants are associated with
increased risk of Parkinson's disease. TMEM175 is the ubiquitous lysosomal K+ channel …

Loss-of-function mutations in the KV4. 3 channel-encoding KCND3 gene are linked to
neurodegenerative cerebellar ataxia. Patients suffering from neurodegeneration associated …

Spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of autosomal
dominant movement disorders. Among the SCAs associated with impaired ion channel …