The probabilistic model of Alzheimer disease: the amyloid hypothesis revised
The current conceptualization of Alzheimer disease (AD) is driven by the amyloid
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
Alzheimer's disease
In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …
[HTML][HTML] Longevity factor klotho enhances cognition in aged nonhuman primates
Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with
klotho, a longevity factor, could enhance cognition in human-relevant models such as in …
klotho, a longevity factor, could enhance cognition in human-relevant models such as in …
APOE genotype and Alzheimer disease risk across age, sex, and population ancestry
Importance Apolipoprotein E (APOE)* 2 andAPOE* 4 are, respectively, the strongest
protective and risk-increasing, common genetic variants for late-onset Alzheimer disease …
protective and risk-increasing, common genetic variants for late-onset Alzheimer disease …
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches
A Serrano-Pozo, S Das, BT Hyman - The Lancet Neurology, 2021 - thelancet.com
The APOE ε4 allele remains the strongest genetic risk factor for sporadic Alzheimer's
disease and the APOE ε2 allele the strongest genetic protective factor after multiple large …
disease and the APOE ε2 allele the strongest genetic protective factor after multiple large …
[HTML][HTML] Aging-suppressor Klotho: Prospects in diagnostics and therapeutics
CR Abraham, A Li - Ageing Research Reviews, 2022 - Elsevier
Abstract Introduction The protein Klotho (KL) was first discovered in KL-deficient mice, which
developed a syndrome similar to premature aging in humans. Since then, KL has been …
developed a syndrome similar to premature aging in humans. Since then, KL has been …
[HTML][HTML] Step by step: towards a better understanding of the genetic architecture of Alzheimer's disease
JC Lambert, A Ramirez, B Grenier-Boley… - Molecular …, 2023 - nature.com
Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …
of this component has progressed over the last 10 years, thanks notably to the advent of …
[HTML][HTML] Protective genes and pathways in Alzheimer's disease: moving towards precision interventions
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that is characterized
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …
[HTML][HTML] Translational approaches to understanding resilience to Alzheimer's disease
Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …
[HTML][HTML] Molecular biomarkers and their implications for the early diagnosis of selected neurodegenerative diseases
J Doroszkiewicz, M Groblewska, B Mroczko - International Journal of …, 2022 - mdpi.com
The degeneration and dysfunction of neurons are key features of neurodegenerative
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …