Apoptosis, a major hallmark of cancer cells, regulates cellular fate and homeostasis. BCL-2
(B-cell CLL/Lymphoma 2) protein family is popularly known to mediate the intrinsic mode of …

Abstract Ecteinascidin 743 (Et-743), also known by the trade name Yondelis®, is the
pioneering marine natural product to be successfully developed as an antitumor drug …

Background The leading cause of cancer-related mortality worldwide is lung cancer, and its
clinical outcome and prognosis are still unsatisfactory. The understanding of potential …

We report on an innovative ligand discovery strategy based on protein NMR-based
screening of a combinatorial library of∼ 125,000 compounds that was arranged in 96 …

In recent years, the number of cancers has soared, becoming one of the leading causes of
human death. At the same time, marine anticancer substances have been the focus of …

Herein, we present the synthesis and biological activity of novel Schiff bases, namely 2-(((2-
((2-hydroxyethyl) amino) ethyl) imino) methyl) phenol (L1) and 4-bromo-2-(((2-((2 …

Marine natural products are known for their diverse chemical structures and extensive
bioactivities. Renieramycins, the member of tetrahydroisoquinoline family of marine natural …

Akt is a key regulatory protein of cancer stem cells (CSCs) and is responsible for cancer
aggressiveness and metastasis. Targeting Akt is beneficial for the development of cancer …

As one of marine tetrahydroisoquinoline alkaloids, renieramycin T plays a significant role in
inhibiting tumor metastasis and invasion. However, the effect of renieramycin T on …

A new practical synthesis of Pt-650, zalypsis and renieramycin T is achieved by employing a
Pictet− Spengler cyclization coupling of the tetrahydroisoquinoline and phenylalaninol …