Zebrafish: development of a vertebrate model organism

JR Meyers - Current Protocols Essential Laboratory …, 2018 - Wiley Online Library
Zebrafish (Danio rerio) are a small‐bodied tropical, freshwater fish species originally from
South Asia. The ease of care, year‐round prolific breeding, and transparent, external …

Signalling dynamics in vertebrate segmentation

A Hubaud, O Pourquié - Nature reviews Molecular cell biology, 2014 - nature.com
Segmentation of the paraxial mesoderm is a major event of vertebrate development that
establishes the metameric patterning of the body axis. This process involves the periodic …

[PDF][PDF] LlamaTags: a versatile tool to image transcription factor dynamics in live embryos

JP Bothma, MR Norstad, S Alamos, HG Garcia - Cell, 2018 - cell.com
Embryonic cell fates are defined by transcription factors that are rapidly deployed, yet
attempts to visualize these factors in vivo often fail because of slow fluorescent protein …

The clockwork embryo: Mechanisms regulating developmental rate

M Diaz-Cuadros, O Pourquié - Annual Review of Genetics, 2023 - annualreviews.org
Organismal development requires the reproducible unfolding of an ordered sequence of
discrete steps (cell fate determination, migration, tissue folding, etc.) in both time and space …

[HTML][HTML] Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes

K Keseroglu, OQH Zinani, S Keskin, H Seawall… - Nature …, 2023 - nature.com
Mutations of several genes cause incomplete penetrance and variable expressivity of
phenotypes, which are usually attributed to modifier genes or gene-environment …

[HTML][HTML] What are you synching about? Emerging complexity of Notch signaling in the segmentation clock

OF Venzin, AC Oates - Developmental biology, 2020 - Elsevier
The Segmentation clock is a population of cellular genetic oscillators, located in the
posterior of the elongating vertebrate embryo, that governs the rhythmic and sequential …

Biological clocks, rhythms, and oscillations: the theory of biological timekeeping

DB Forger - 2017 - books.google.com
An introduction to the mathematical, computational, and analytical techniques used for
modeling biological rhythms, presenting tools from many disciplines and example …

Periodic inhibition of Erk activity drives sequential somite segmentation

MF Simsek, AS Chandel, D Saparov, OQH Zinani… - Nature, 2023 - nature.com
Sequential segmentation creates modular body plans of diverse metazoan embryos,,–.
Somitogenesis establishes the segmental pattern of the vertebrate body axis. A molecular …

Pairing of segmentation clock genes drives robust pattern formation

OQH Zinani, K Keseroğlu, A Ay, EM Özbudak - Nature, 2021 - nature.com
Gene expression is an inherently stochastic process,; however, organismal development
and homeostasis require cells to coordinate the spatiotemporal expression of large sets of …

Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation

M Boareto, D Iber, V Taylor - Development, 2017 - journals.biologists.com
During embryonic and adult neurogenesis, neural stem cells (NSCs) generate the correct
number and types of neurons in a temporospatial fashion. Control of NSC activity and fate is …