The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …

Light exerts a range of powerful biological effects beyond image vision, including mood and
learning regulation. While the source of photic information affecting mood and cognitive …

A majority of mammalian genes exhibit daily fluctuations in expression levels, making
circadian expression rhythms the largest known regulatory network in normal physiology …

Circadian rhythms (CR) are a series of endogenous autonomous oscillators generated by
the molecular circadian clock which acting on coordinating internal time with the external …

Mammals rely on a network of circadian clocks to control daily systemic metabolism and
physiology. The central pacemaker in the suprachiasmatic nucleus (SCN) is considered …

Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …

The pineal hormone melatonin has attracted great scientific interest since its discovery in
1958. Despite the enormous number of basic and clinical studies the exact role of melatonin …

The purposes of this paper are to provide an overview of the state of the science of sleep in
children with autism spectrum disorder (ASD), present hypotheses for the high prevalence of …

SIRT1 is a NAD+-dependent protein deacetylase that governs many physiological
pathways, including circadian rhythm in peripheral tissues. Here, we show that SIRT1 in the …