Molecular motors are protein machines whose directed movement along cytoskeletal
filaments is driven by ATP hydrolysis. Eukaryotic cells contain motors that help to transport …

The fundamental basis of muscle contraction 'the sliding filament model'(;) and the 'swinging,
tilting crossbridge-sliding filament mechanism'(;) nucleated a field of research that has …

No biological system has been studied by more diverse approaches than the actin-based
molecular motor myosin. Biophysics, biochemistry, physiology, classical genetics and …

THE MDM2 proto-oncogene is found amplified in a variety of tumours1. The oncogenic
capacity of the MDM2 protein is attributed to its ability to bind the p53 tumour-suppressor …

It is now firmly established that the contraction of muscle and many of the movements of
nonmuscle cells result from the interaction of two proteins, actin and myosin. These …

The mechanics of the actomyosin interaction have been extensively studied using the
organized filament array of striated muscle. However, the extrapolation of these data to the …

A number of recent observations by probe and X-ray methods on the behaviour of
crossbridges during contraction is considered in relation to the energetics of the process. It is …

Step changes in length (between− 3 and+ 5nm per half-sarcomere) were imposed on
isolated muscle fibers at the plateau of an isometric tetanus (tension T 0) and on the same …

A new method is described for measuring motions of protein domains in their native
environment on the physiological timescale. Pairs of cysteines are introduced into the …

The mechanical load borne by a molecular motor affects its force, sliding distance, and its
rate of energy transduction. The control of ATPase activity by the mechanical load on a …