Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

Background Despite recent efforts and successes in reducing the malaria burden globally,
this infection still accounts for an estimated 212 million clinical cases, 2 million severe …

Since the turn of the century, a remarkable expansion has been achieved in the range and
effectiveness of products and strategies available to prevent, treat, and control malaria …

Background Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality
in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been …

Abstract Background Acidosis in severe Plasmodium falciparum malaria is associated with
high mortality, yet the pathogenesis remains incompletely understood. The aim of this study …

Currently recommended methods of assessing the efficacy of uncomplicated falciparum
malaria treatment work less well in high-transmission than in low-transmission settings …

Background Liberal fluid resuscitation has proved harmful in adults with severe malaria, but
the level of restriction has not been defined. Methods In a prospective observational study in …

Background Severe malaria is a life-threatening infection, particularly affecting children
under the age of 5 years in Africa. Current treatment with parenteral artemisinin derivatives …

Objectives We tested the hypothesis that adjunctive rosiglitazone treatment would reduce
levels of circulating angiopoietin-2 (Angpt-2) and improve outcomes of Mozambican children …

Background The present study aimed to evaluate the management of severe malaria at
Gezira State hospitals in Sudan by assessing hospital readiness, health care provider …