Zoonotic potential of influenza A viruses: a comprehensive overview

A Mostafa, EM Abdelwhab, TC Mettenleiter, S Pleschka - Viruses, 2018 - mdpi.com
Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect
different avian and mammalian animal hosts, from which they can be transmitted to humans …

Inventory of molecular markers affecting biological characteristics of avian influenza A viruses

A Suttie, YM Deng, AR Greenhill, P Dussart… - Virus genes, 2019 - Springer
Avian influenza viruses (AIVs) circulate globally, spilling over into domestic poultry and
causing zoonotic infections in humans. Fortunately, AIVs are not yet capable of causing …

[HTML][HTML] Catalytic inactivation of influenza virus by iron oxide nanozyme

T Qin, R Ma, Y Yin, X Miao, S Chen, K Fan, J Xi… - Theranostics, 2019 - ncbi.nlm.nih.gov
Influenza poses a severe threat to human health in the world. However, developing a
universal anti-viral strategy has remained challenging due to the presence of diverse …

Selective degradation of host RNA polymerase II transcripts by influenza A virus PA-X host shutoff protein

DA Khaperskyy, S Schmaling, J Larkins-Ford… - PLoS …, 2016 - journals.plos.org
Influenza A viruses (IAVs) inhibit host gene expression by a process known as host shutoff.
Host shutoff limits host innate immune responses and may also redirect the translation …

The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression

L Gaucherand, BK Porter, RE Levene, EL Price… - Cell reports, 2019 - cell.com
Many viruses shut off host gene expression to inhibit antiviral responses. Viral proteins and
host proteins required for viral replication are typically spared in this process, but the …

Modulation of innate immune responses by the influenza A NS1 and PA-X proteins

A Nogales, L Martinez-Sobrido, DJ Topham… - Viruses, 2018 - mdpi.com
Influenza A viruses (IAV) can infect a broad range of animal hosts, including humans. In
humans, IAV causes seasonal annual epidemics and occasional pandemics, representing a …

Cut site preference allows influenza A virus PA-X to discriminate between host and viral mRNAs

L Gaucherand, A Iyer, I Gilabert, CH Rycroft… - Nature …, 2023 - nature.com
Many viruses block host gene expression to take over the infected cell. This process, termed
host shutoff, is thought to promote viral replication by preventing antiviral responses and …

The role of viral RNA degrading factors in shutoff of host gene expression

L Gaucherand, MM Gaglia - Annual review of virology, 2022 - annualreviews.org
Many viruses induce shutoff of host gene expression (host shutoff) as a strategy to take over
cellular machinery and evade host immunity. Without host shutoff activity, these viruses …

Roles of the non-structural proteins of influenza A virus

W Hao, L Wang, S Li - Pathogens, 2020 - mdpi.com
Influenza A virus (IAV) is a segmented, negative single-stranded RNA virus that causes
seasonal epidemics and has a potential for pandemics. Several viral proteins are not …

Shutoff of host gene expression in influenza A virus and herpesviruses: similar mechanisms and common themes

HG Rivas, SK Schmaling, MM Gaglia - Viruses, 2016 - mdpi.com
The ability to shut off host gene expression is a shared feature of many viral infections, and it
is thought to promote viral replication by freeing host cell machinery and blocking immune …