Intricacies of TGF-β signaling in Treg and Th17 cell biology
Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …
central to the balance between immune tolerance and immune rejection. Th cells adopt …
Helper T cell differentiation
CD4+ T helper cells are key regulators of host health and disease. In the original model,
specialized subsets of T helper cells are generated following activation through lineage …
specialized subsets of T helper cells are generated following activation through lineage …
Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk
Coronary artery disease (CAD) is a complex inflammatory disease involving genetic
influences across cell types. Genome-wide association studies have identified over 200 loci …
influences across cell types. Genome-wide association studies have identified over 200 loci …
Engineered nanomaterials for synergistic photo-immunotherapy
R Guo, S Wang, L Zhao, Q Zong, T Li, G Ling, P Zhang - Biomaterials, 2022 - Elsevier
Nanomaterial-synergized photodynamic therapy (PDT) and photothermal therapy (PTT), as
efficient and non-invasive treatment modalities, have shown significant advantages in …
efficient and non-invasive treatment modalities, have shown significant advantages in …
Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases
N Ohkura, S Sakaguchi - Cell research, 2020 - nature.com
Naturally arising regulatory CD4+ T (Treg) cells, which specifically express the transcription
factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell …
factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell …
The immunogenetics of psoriasis: a comprehensive review
JL Harden, JG Krueger, AM Bowcock - Journal of autoimmunity, 2015 - Elsevier
Psoriasis vulgaris is a common, chronic inflammatory skin disease with a complex etiology
involving genetic risk factors and environmental triggers. Here we describe the many known …
involving genetic risk factors and environmental triggers. Here we describe the many known …
The alarmin IL-33 promotes regulatory T-cell function in the intestine
C Schiering, T Krausgruber, A Chomka, A Fröhlich… - Nature, 2014 - nature.com
FOXP3+ regulatory T cells (Treg cells) are abundant in the intestine, where they prevent
dysregulated inflammatory responses to self and environmental stimuli. It is now appreciated …
dysregulated inflammatory responses to self and environmental stimuli. It is now appreciated …
CRISPR screen in regulatory T cells reveals modulators of Foxp3
Regulatory T (Treg) cells are required to control immune responses and maintain
homeostasis, but are a significant barrier to antitumour immunity. Conversely, Treg …
homeostasis, but are a significant barrier to antitumour immunity. Conversely, Treg …
Differentiation of effector CD4 T cell populations
CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They
are also involved in autoimmunity, asthma, and allergic responses as well as in tumor …
are also involved in autoimmunity, asthma, and allergic responses as well as in tumor …
RUNX transcription factors: orchestrators of development
ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
including basic cellular and developmental processes, stem cell biology and tumorigenesis …