Background: Mutations in breast cancer susceptibility genes (BRCA1 and BRCA2) are
associated with increased risks for breast, ovarian, and other types of cancer. Purpose: To …

Women who are at high risk of breast cancer can be offered more intensive surveillance or
prophylactic measures, such as surgery or chemoprevention. Central to decisions regarding …

A population-based series of 649 unselected incident cases of ovarian cancer diagnosed in
Ontario, Canada, during 1995–96 was screened for germline mutations in BRCA1 and …

The number of available breast cancer cell (BCC) lines is small, and only a very few of them
have been extensively studied. Whether they are representative of the tumours from which …

This book employs a careful, rigorous, yet lively approach to the timely question of whether
we can justly generalize about members of a group on the basis of statistical tendencies of …

Purpose To define a gene expression profile of BRCA ness that correlates with
chemotherapy response and outcome in epithelial ovarian cancer (EOC). Methods A …

Numerous models have been developed to quantify the combined effect of various risk
factors to predict either risk of developing breast cancer, risk of carrying a high-risk germline …

Germline mutations in the BRCA1 or BRCA2 tumour-suppressor genes are strong predictors
of breast and/or ovarian cancer development. The contribution of these mutations to breast …

ContextMost hereditary ovarian cancers are associated with germline mutations in BRCA1
or BRCA2. Attempts to define the clinical significance of BRCA mutation status in ovarian …

PURPOSE: To compare genetic test results for deleterious mutations of BRCA1 and BRCA2
with estimated probabilities of carrying such mutations; to assess sensitivity of genetic …