Among a litany of malignancies affecting the female reproductive tract, that of the ovary is the
most frequently fatal. Moreover, while the steady pace of scientific discovery has fuelled …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

Recent genome sequencing efforts have identified millions of somatic mutations in cancer.
However, the functional impact of most variants is poorly understood. Here we characterize …

Cancer genome characterization efforts now provide an initial view of the somatic alterations
in primary tumors. However, most point mutations occur at low frequency, and the function of …

Chromosomal instability is a major challenge to patient stratification and targeted drug
development for high-grade serous ovarian carcinoma (HGSOC). Here we show that …

Methods that integrate molecular network information and tumor genome data could
complement gene-based statistical tests to identify likely new cancer genes; but such …

Hereditary breast and ovarian cancer syndrome carries significant mortality for young
women if effective preventive and screening measures are not taken. Preventive salpingo …

Biotin-based labeling strategies are widely employed to study protein-protein interactions,
subcellular proteomes and post-translational modifications, as well as, used in drug …

Breast cancer is the second most frequently occurring form of cancer and is also the second
most lethal cancer in women worldwide. A genetic mutation is one of the key factors that …

The docking proteins of the Grb-associated binder (Gab) family transduce cellular signals
between receptors and intracellular downstream effectors, and provide a platform for protein …