MCP-1: Function, regulation, and involvement in disease

S Singh, D Anshita, V Ravichandiran - International immunopharmacology, 2021 - Elsevier
Abstract MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif)
ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of …

Diabetic macular edema: current understanding, molecular mechanisms and therapeutic implications

J Zhang, J Zhang, C Zhang, J Zhang, L Gu, D Luo… - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), with increasing incidence, is the major cause of vision loss and
blindness worldwide in working-age adults. Diabetic macular edema (DME) remains the …

Endothelial dysfunction in diabetic retinopathy

F Gui, Z You, S Fu, H Wu, Y Zhang - Frontiers in Endocrinology, 2020 - frontiersin.org
Diabetic retinopathy (DR) is a diabetic complication which affects retinal function and results
in severe loss of vision and relevant retinal diseases. Retinal vascular dysfunction caused …

The role of inflammation in immune system of diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications

T Yue, Y Shi, S Luo, J Weng, Y Wu… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy is one of the most common complications of diabetes mellitus and the
leading cause of low vision and blindness worldwide. Mounting evidence demonstrates that …

Role of CCL2/CCR2 axis in the pathogenesis of COVID-19 and possible Treatments: All options on the Table

M Ranjbar, A Rahimi, Z Baghernejadan… - International …, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is cause of the novel
coronavirus disease (COVID-19). In the last two years, SARS-CoV-2 has infected millions of …

The role of inflammation in diabetic eye disease

M Mesquida, F Drawnel, S Fauser - Seminars in Immunopathology, 2019 - Springer
Mounting evidence suggests that immunological mechanisms play a fundamental role in the
pathogenesis of diabetic retinopathy (DR) and diabetic macular edema (DME). Upregulation …

Role of CCL2/CCR2 axis in the immunopathogenesis of rheumatoid arthritis: Latest evidence and therapeutic approaches

F Moadab, H Khorramdelazad, M Abbasifard - Life Sciences, 2021 - Elsevier
Evidence suggests that uncontrolled immune system responses and their components play
a significant role in developing rheumatoid arthritis (RA), which is considered an …

[HTML][HTML] Small extracellular vesicle-loaded bevacizumab reduces the frequency of intravitreal injection required for diabetic retinopathy

SK Reddy, AR Ballal, S Shailaja, RN Seetharam… - Theranostics, 2023 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR) is associated with retinal neovascularization, hard exudates,
inflammation, oxidative stress and cell death, leading to vision loss. Anti-vascular …

Ocular vascular diseases: from retinal immune privilege to inflammation

X Wang, T Wang, E Lam, D Alvarez, Y Sun - International Journal of …, 2023 - mdpi.com
The eye is an immune privileged tissue that insulates the visual system from local and
systemic immune provocation to preserve homeostatic functions of highly specialized retinal …

RIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathy

Z Huang, J Liang, S Chen, TK Ng, ME Brelén… - Cell Death & …, 2023 - nature.com
Diabetic retinopathy (DR) is a leading cause of blindness that poses significant public health
concerns worldwide. Increasing evidence suggests that neuroinflammation plays a key role …