Sources of vascular nitric oxide and reactive oxygen species and their regulation

J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model

LWD Weber, M Boll, A Stampfl - Critical reviews in toxicology, 2003 - Taylor & Francis
The use of many halogenated alkanes such as carbon tetrachloride (CCl4), chloroform
(CHCl3) or iodoform (CHI3), has been banned or severely restricted because of their distinct …

Oxidative stress-related molecules and liver fibrosis

M Parola, G Robino - Journal of hepatology, 2001 - Elsevier
Liver fibrosis can be considered as a dynamic and highly integrated cellular response to
chronic liver injury [1]. Whatever the etiology, the evolution of chronic liver disease (CLD) is …

Inducible nitric oxide synthase and inflammatory diseases

R Zamora, Y Vodovotz, TR Billiar - Molecular medicine, 2000 - Springer
Nitric oxide (NO) is a colorless gas at room temperature and one of the simplest molecules
known, yet it has been implicated in a wide variety of regulatory mechanisms ranging from …

Alcohol, oxidative stress and free radical damage

E Albano - Proceedings of the nutrition society, 2006 - cambridge.org
The involvement of free radical mechanisms in the pathogenesis of alcoholic liver disease
(ALD) is demonstrated by the detection of lipid peroxidation markers in the liver and the …

Redox mechanisms in hepatic chronic wound healing and fibrogenesis

E Novo, M Parola - Fibrogenesis & tissue repair, 2008 - Springer
Reactive oxygen species (ROS) generated within cells or, more generally, in a tissue
environment, may easily turn into a source of cell and tissue injury. Aerobic organisms have …

Nitric oxide in mucosal defense: a little goes a long way

JL Wallace, MJS Miller - Gastroenterology, 2000 - Elsevier
Nitric oxide (NO) is now recognized as an important modulator of an enormous number of
physiological processes, ranging from blood pressure regulation to neuronal transmission to …

The regulatory role of nitric oxide in apoptosis

PKM Kim, R Zamora, P Petrosko, TR Billiar - International …, 2001 - Elsevier
Nitric oxide (NO) is a multi-faceted molecule with dichotomous regulatory roles in many
areas of biology. The complexity of its biological effects is a consequence of its numerous …

Mechanisms of liver cell injury

N Kaplowitz - Journal of hepatology, 2000 - Elsevier
Liver cell death is triggered by a number of insults arising from the external environment or
from within the cell. These insults may engage cell surface receptors with death domaines …

Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection

GL Tipoe, TM Leung, MW Hung… - … Disorders-Drug Targets …, 2007 - ingentaconnect.com
Our review aims to examine the cellular and molecular mechanisms of cardiovascular
protection of green tea polyphenols, particularly epigallocatechin gallate (EGCG), which …