Selenium (Se)-containing compounds have attracted a growing interest as anticancer
agents over recent decades, with mounting reports demonstrating their high efficacy and …

The biological activity of selenium is dependent upon its speciation. We aim to integrate
selenium speciation and metabolism into a discussion of the mechanisms by which …

Tumor cells are characterized as redox-heterogeneous intracellular microenvironment due
to the simultaneous overproduction of reactive oxygen species and glutathione. Rational …

Functions of selenium are diverse as antioxidant, anti-inflammation, increased immunity,
reduced cancer incidence, blocking tumor invasion and metastasis, and further clinical …

There are several selenocompounds in tissues of plants and animals. Selenate is the major
inorganic selenocompound found in both animal and plant tissues. Selenocysteine is the …

Reactive oxygen species (ROS), as well as reactive nitrogen species (RNS) play either
harmful or beneficial role in biological systems. Beneficial effects of ROS include …

Epidemiological studies, preclinical investigations and clinical intervention trials support the
role of selenium compounds as potent cancer chemopreventive agents; the dose and the …

Methylselenol from selenium metabolism is postulated to be and most experimental
evidence now indicates that it is the selenium metabolite responsible for the dietary …

Selenium is a main group element and an essential trace element in human health. It was
discovered in selenocysteine (SeC) by Stadtman in 1974. SeC is an encoded natural amino …

In utero ethanol exposure elicits apoptotic cell death in the fetal brain, and this may be
mediated by oxidative stress. Our studies utilize cultured fetal rat cortical neurons and …