Genome-wide discovery efforts have identified more than 500 genetic loci associated with
adiposity traits. The vast majority of these loci were found through large-scale meta-analyses …

Recent developments in genetics and genomics are providing a detailed and systematic
characterization of the genetic underpinnings of common metabolic diseases and traits …

Domestication and selective breeding has resulted in over 1000 extant cattle breeds. Many
of these breeds do not excel in important traits but are adapted to local environments. These …

Aims/hypothesis The A (minor) allele of CREBRF rs373863828 has been associated with
increased BMI and reduced risk of type 2 diabetes in the Samoan populations of Samoa and …

Obesity prevalence continues to rise worldwide, posing a substantial burden on people's
health. However, up to 45% of obese individuals do not suffer from cardiometabolic …

Aims/hypothesis Variants in CREBRF (rs12513649 and rs373863828) have been strongly
associated with increased BMI and decreased risk of type 2 diabetes in Polynesian …

Abstract Background/objectives: In Samoa, where 80% of the adult population is living with
obesity, understanding the determinants of adiposity and growth during infancy may inform …

Statistical imputation applied to genome-wide array data is the most cost-effective approach
to complete the catalog of genetic variation in a study population. However, imputed …

Background Paediatric obesity has reached epidemic proportions globally, resulting in
significant adverse effects on health and wellbeing. Early life events, including those that …

Background The prevalence of obesity and diabetes in Samoa, like many other Pacific
Island nations, has reached epidemic proportions. Although the etiology of these conditions …