The genetics of adiposity

RJF Loos - Current opinion in genetics & development, 2018 - Elsevier
Genome-wide discovery efforts have identified more than 500 genetic loci associated with
adiposity traits. The vast majority of these loci were found through large-scale meta-analyses …

The genetic basis of metabolic disease

I Barroso, MI McCarthy - Cell, 2019 - cell.com
Recent developments in genetics and genomics are providing a detailed and systematic
characterization of the genetic underpinnings of common metabolic diseases and traits …

Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation

AA Yurchenko, HD Daetwyler, N Yudin, RD Schnabel… - Scientific reports, 2018 - nature.com
Domestication and selective breeding has resulted in over 1000 extant cattle breeds. Many
of these breeds do not excel in important traits but are adapted to local environments. These …

Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living …

M Krishnan, TJ Major, RK Topless, O Dewes, L Yu… - Diabetologia, 2018 - Springer
Aims/hypothesis The A (minor) allele of CREBRF rs373863828 has been associated with
increased BMI and reduced risk of type 2 diabetes in the Samoan populations of Samoa and …

Genes that make you fat, but keep you healthy

RJF Loos, TO Kilpeläinen - Journal of internal medicine, 2018 - Wiley Online Library
Obesity prevalence continues to rise worldwide, posing a substantial burden on people's
health. However, up to 45% of obese individuals do not suffer from cardiometabolic …

Association of CREBRF variants with obesity and diabetes in Pacific Islanders from Guam and Saipan

RL Hanson, S Safabakhsh, JM Curtis, WC Hsueh… - Diabetologia, 2019 - Springer
Aims/hypothesis Variants in CREBRF (rs12513649 and rs373863828) have been strongly
associated with increased BMI and decreased risk of type 2 diabetes in Polynesian …

A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants

KJ Arslanian, UT Fidow, T Atanoa… - International journal of …, 2021 - nature.com
Abstract Background/objectives: In Samoa, where 80% of the adult population is living with
obesity, understanding the determinants of adiposity and growth during infancy may inform …

Population-specific reference panels are crucial for genetic analyses: an example of the CREBRF locus in Native Hawaiians

M Lin, C Caberto, P Wan, Y Li… - Human molecular …, 2020 - academic.oup.com
Statistical imputation applied to genome-wide array data is the most cost-effective approach
to complete the catalog of genetic variation in a study population. However, imputed …

Childhood obesity in New Zealand

V Chiavaroli, JD Gibbins, WS Cutfield… - World Journal of …, 2019 - Springer
Background Paediatric obesity has reached epidemic proportions globally, resulting in
significant adverse effects on health and wellbeing. Early life events, including those that …

[HTML][HTML] Exploring the paradoxical relationship of a Creb 3 regulatory factor missense variant with body mass index and diabetes among Samoans: Protocol for the …

NL Hawley, A Pomer, AC Rivara… - JMIR Research …, 2020 - researchprotocols.org
Background The prevalence of obesity and diabetes in Samoa, like many other Pacific
Island nations, has reached epidemic proportions. Although the etiology of these conditions …