BackgroundConverging lines of evidence implicate an important role for the immune system
in schizophrenia. Microglia are the resident immune cells of the central nervous system and …

Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but
this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycoprotein …

An interaction between external stressors and intrinsic vulnerability is one of the longest
standing pathoaetiological explanations for schizophrenia. However, novel lines of evidence …

Blood–brain barrier pathology is recognised as a central factor in the development of many
neurological disorders, but much less is known about the role of the blood–brain barrier in …

The role of immune activation in psychiatric disorders has attracted considerable attention
over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the …

Inflammation regulates neurogenesis, and the brains of patients with schizophrenia and
bipolar disorder have reduced expression of neurogenesis markers in the subependymal …

This narrative review examines the possible role of microglial cells, first, in
neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research …

A great deal of interest in psychiatric research is currently centered upon the pathogenic role
of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands …

The pathophysiology of dopamine dysregulation in schizophrenia involves alterations at the
ventral midbrain level. Given that inflammatory mediators such as cytokines influence the …

Microglia, the immune cells of the brain, are important for neurodevelopment and have been
hypothesized to play a role in the pathogenesis of schizophrenia (SCZ). Although previous …