TGF‐β superfamily co‐receptors in cancer
Transforming growth factor‐β (TGF‐β) superfamily signaling via their cognate receptors is
frequently modified by TGF‐β superfamily co‐receptors. Signaling through SMAD‐mediated …
frequently modified by TGF‐β superfamily co‐receptors. Signaling through SMAD‐mediated …
The biology of SCUBE
Abstract The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial
growth factor domain-containing protein] family consists of three proteins in vertebrates …
growth factor domain-containing protein] family consists of three proteins in vertebrates …
CAFs-derived SCUBE1 promotes malignancy and stemness through the Shh/Gli1 pathway in hepatocellular carcinoma
J Zhao, R Li, J Li, Z Chen, Z Lin, B Zhang… - Journal of Translational …, 2022 - Springer
Background The tumour microenvironment and cirrhotic liver are excellent sources of cancer-
associated fibroblasts (CAFs), which participate in carcinogenesis. Thus, it is important to …
associated fibroblasts (CAFs), which participate in carcinogenesis. Thus, it is important to …
Proteomic approaches in biomarker discovery: new perspectives in cancer diagnostics
P Hudler, N Kocevar, R Komel - The scientific world journal, 2014 - Wiley Online Library
Despite remarkable progress in proteomic methods, including improved detection limits and
sensitivity, these methods have not yet been established in routine clinical practice. The …
sensitivity, these methods have not yet been established in routine clinical practice. The …
The multifaceted role of signal peptide-CUB-EGF domain-containing protein (SCUBE) in cancer
Signal peptide, CUB, and EGF-like domain-containing proteins (SCUBE) are secretory cell
surface glycoproteins that play key roles in the developmental process. SCUBE proteins …
surface glycoproteins that play key roles in the developmental process. SCUBE proteins …
Can signal peptide-CUB-EGF domain-containing protein (SCUBE) levels be a marker of angiogenesis in patients with psoriasis?
Angiogenesis is an important process being involved in the pathogenesis of psoriasis and
promises new potential parameter for diagnosis and screening of treatment. This study …
promises new potential parameter for diagnosis and screening of treatment. This study …
[HTML][HTML] SCUBE1: a promising biomarker in renal cell cancer
Purpose To investigate the efficacy of signal peptide-CUB-EGF domain-containing protein 1
(SCUBE-1) as a novel biomarker of renal tumors. Materials and Methods 48 individuals …
(SCUBE-1) as a novel biomarker of renal tumors. Materials and Methods 48 individuals …
Elevated serum levels of SCUBE1, a marker for coagulation, in patients with breast cancer
Breast cancer (BC) is the most common cancer among women and a major cause of death.
Signal Peptide-Cub-Epidermal growth factor domain-containing protein-1 (SCUBE1) is …
Signal Peptide-Cub-Epidermal growth factor domain-containing protein-1 (SCUBE1) is …
[HTML][HTML] The diagnostic and prognostic significance of SCUBE1 levels in Crimean-Congo hemorrhagic fever
Background The new biochemical marker, signal peptide-CUB-EGF domain-containing
protein 1 (SCUBE1), is secreted and cell surface glycoprotein expressed during early …
protein 1 (SCUBE1), is secreted and cell surface glycoprotein expressed during early …
[HTML][HTML] Overexpression of SCUBE2 inhibits proliferation, migration, and invasion in glioma cells
E Guo, H Liu, X Liu - Oncology Research, 2017 - ncbi.nlm.nih.gov
Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the
SCUBE family of proteins, was recently found to play an important role in cancer …
SCUBE family of proteins, was recently found to play an important role in cancer …