Glioblastoma (GBM) is the most common high-grade primary malignant brain tumor with an
extremely poor prognosis. Given the poor survival with currently approved treatments for …

Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive
molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has …

Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc.
The interactions between these components, which are divided into anti-tumor and pro …

Immune checkpoint blockade therapies have shown clinical promise in a variety of cancers,
but how tumor-infiltrating T cells are activated remains unclear. In this study, we explore the …

Glioblastoma is the most common primary malignant brain tumor in adults and is associated
with poor survival. The Ivy Foundation Early Phase Clinical Trials Consortium conducted a …

Melanoma, a skin cancer associated with high mortality rates, is highly radio-and
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …

PARP inhibitors (PARPi) have shown remarkable therapeutic efficacy against BRCA1/2-
mutant cancers through a synthetic lethal interaction. PARPi exert their therapeutic effects …

Abstract Purpose: Hyperprogression (HP), a paradoxical boost in tumor growth, was
described in a subset of patients treated with immune checkpoint inhibitors (ICI). Neither …

Background Immunotherapies have demonstrated efficacy across a diverse set of tumors
supporting further evaluation in glioblastoma. The objective of this study was to evaluate the …