Neurotensin (NTS) has long been recognized as a neurotransmitter or neuromodulator in
the central nervous system and as an endocrine agent in the periphery via actions mediated …

Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for
combinatorial as well as medicinal chemistry. This review presents a detailed overview on …

Background: Along with the progress in medicine and therapies, the exploitation of anti-
cancer agents focused more on the vital signaling pathways and key biological …

Methods: Cells treated with SR48692, a selective antagonist of NTSR1, or NTSR1 shRNA
were stained with Annexin V-FITC/PI and the apoptosis was assessed by flow cytometry …

Muramyl dipeptide (MDP) is the smallest essential peptidoglycan substructure capable of
promoting both innate and adaptive immune responses. Herein, we report on the design …

Compounds active at neurotensin receptors (NTS1 and NTS2) exert analgesic effects on
different types of nociceptive modalities, including thermal, mechanical, and chemical …

Neurotensin receptor 1 (NTS1) is involved in the development and progression of numerous
cancers, which makes it an interesting target for the development of diagnostic and …

Sortilin is a member of the vacuolar protein sorting 10 protein (VPS10P) domain receptor
family, which carries out signal transduction and protein transport in cells. Sortilin serves as …

An ester condensation between 3, 5-diacetyl-2, 6-dimethylpyridine and an excess of diethyl
oxalate was used for the preparation of 4, 4'(2, 6-dimethylpyridine-3, 5-diyl) bis (2-hydroxy-4 …

Neurotensin (NT) is a peptide involved in digestion, neuromodulation, and cancer
progression. NT and its receptors (NTR1 and SORT1 mainly) have been widely studied in …