The essential role of the brain in maintaining energy homeostasis has motivated the drive to
define the neural circuitry that integrates external and internal stimuli to enact appropriate …

The overconsumption of highly caloric and palatable foods has caused a surge in obesity
rates in the past half century, thereby posing a healthcare challenge due to the array of …

Abstract Pro-opiomelanocortin (POMC)-and agouti-related peptide (AgRP)-expressing
neurons of the arcuate nucleus of the hypothalamus (ARC) are oppositely regulated by …

The sympathetic nervous system maintains metabolic homeostasis by orchestrating the
activity of organs such as the pancreas, liver, and white and brown adipose tissues. From …

Adipokines secreted from white adipose tissue play a role in metabolic crosstalk and
homeostasis, whereas the brown adipose secretome is less explored. We performed high …

Brown and beige adipocytes arise from distinct developmental origins. Brown adipose tissue
(BAT) develops embryonically from precursors that also give to skeletal muscle. Beige fat …

The hypothalamus–pituitary–thyroid feedback control is a dynamic, adaptive system. In
situations of illness and deprivation of energy representing type 1 allostasis, the stress …

The paraventricular nucleus of the hypothalamus (PVH), located in the ventral diencephalon
adjacent to the third ventricle, is a highly conserved brain region present in species from …

There is growing evidence that oxytocin (OXT), a hypothalamic hormone well recognized for
its effects in inducing parturition and lactation, has important metabolic effects in both sexes …

Summary Glucagon-like Peptide 1 (GLP-1)-expressing neurons in the hindbrain send robust
projections to the paraventricular nucleus of the hypothalamus (PVN), which is involved in …