Nemaline myopathies are a heterogenous group of congenital myopathies caused by de
novo, dominantly or recessively inherited mutations in at least twelve genes. The genes …

Genetic manipulations with a robust and predictable outcome are critical to investigate gene
function, as well as for therapeutic genome engineering. For many years, knockdown …

Mutations play a crucial role in evolution as they provide the genetic variation that allows
evolutionary change. Although some mutations in regulatory elements or coding regions can …

Coronary artery disease (CAD) is the leading form of cardiovascular disease (CVD), which is
the primary cause of mortality worldwide. It is a complex disease with genetic and …

A phenomenon of genetic compensation is commonly observed when an organism with a
disease-bearing mutation shows incomplete penetrance of the disease phenotype. Such …

Transcriptional adaptation is a recently described phenomenon by which a mutation in one
gene leads to the transcriptional modulation of related genes, termed adapting genes. At the …

Genetic compensation is a remarkable biological concept to explain the genetic robustness
in an organism to maintain its fitness and viability if there is a disruption occurred in the …

Genetics has recently benefited from the genome engineering revolution: genes can be
knocked out, knocked down, or activated more easily than ever before. This range of genetic …

The cardiac fibroblast interacts with an extracellular matrix (ECM), enabling myofibroblast
maturation via a process called mechanosensing. Although in the aging male heart, ECM is …

Oviparous vertebrates produce multiple forms of vitellogenin (Vtg), the major source of yolk
nutrients, but little is known about their individual contributions to reproduction and …