[HTML][HTML] Reperfusion cardiac injury: receptors and the signaling mechanisms
LN Maslov, SV Popov… - Current Cardiology …, 2022 - ncbi.nlm.nih.gov
It has been documented that Ca 2+ overload and increased production of reactive oxygen
species play a significant role in reperfusion injury (RI) of cardiomyocytes …
species play a significant role in reperfusion injury (RI) of cardiomyocytes …
Pleiotropic Properties of Valsartan: Do They Result from the Antiglycooxidant Activity? Literature Review and In Vitro Study
KM Mil, ME Gryciuk, C Pawlukianiec… - Oxidative Medicine …, 2021 - Wiley Online Library
Valsartan belongs to angiotensin II type 1 (AT1) receptor blockers (ARB) used in
cardiovascular diseases like heart failure and hypertension. Except for its AT1‐antagonism …
cardiovascular diseases like heart failure and hypertension. Except for its AT1‐antagonism …
Brain-targeted delivery of Valsartan using solid lipid nanoparticles labeled with Rhodamine B; a promising technique for mitigating the negative effects of stroke
The brain is a vital organ that is protected from the general circulation and is distinguished
by the presence of a relatively impermeable blood brain barrier (BBB). Blood brain barrier …
by the presence of a relatively impermeable blood brain barrier (BBB). Blood brain barrier …
Protective effect of valsartan against doxorubicin‐induced cardiotoxicity: Histopathology and metabolomics in vivo study
K Alhazzani, MR Alotaibi, FN Alotaibi… - … of biochemical and …, 2021 - Wiley Online Library
Doxorubicin (DOX) treatment has been associated with cardiotoxicity. Therefore, it is crucial
to search for a therapeutic that can effectively mitigate DOX‐induced cardiotoxicity. This …
to search for a therapeutic that can effectively mitigate DOX‐induced cardiotoxicity. This …
Hydroxytyrosol Protects against Myocardial Ischemia/Reperfusion Injury through a PI3K/Akt‐Dependent Mechanism
Y Pei, J Chen, L Xie, X Cai, RH Yang… - Mediators of …, 2016 - Wiley Online Library
Objective. To investigate the effects and mechanisms of hydroxytyrosol (HT) during the
pathogenesis of myocardial ischemia reperfusion (I/R) in rat hearts. Methods. The rats were …
pathogenesis of myocardial ischemia reperfusion (I/R) in rat hearts. Methods. The rats were …
Preparation and appraisal of self-assembled valsartan-loaded amalgamated Pluronic F127/Tween 80 polymeric micelles: Boosted cardioprotection via regulation of …
HM Aboud, MO Mahmoud… - Journal of drug …, 2020 - Taylor & Francis
This study aimed to develop valsartan (VAL)-loaded mixed micelles and investigate their
cardioprotective potential and molecular mechanisms through Mhrt/Nrf2 and Trx1 pathways …
cardioprotective potential and molecular mechanisms through Mhrt/Nrf2 and Trx1 pathways …
KLF5 overexpression attenuates cardiomyocyte inflammation induced by oxygen-glucose deprivation/reperfusion through the PPARγ/PGC-1α/TNF-α signaling …
Y Li, J Li, Z Hou, Y Yu, B Yu - Biomedicine & Pharmacotherapy, 2016 - Elsevier
The primary physiological function of Krüppel-like zinc-finger transcription factor (KLF5) is
the regulation of cardiovascular remodeling. Vascular remodeling is closely related to the …
the regulation of cardiovascular remodeling. Vascular remodeling is closely related to the …
Valsartan: An Angiotensin Receptor Blocker Modulates BDNF Expression and Provides Neuroprotection Against Cerebral Ischemic Reperfusion Injury
AT1 receptor blockers (ARBs) are commonly used drugs to treat cardiovascular disease and
hypertension, but research on their impact on brain disorders is unattainable. Valsartan …
hypertension, but research on their impact on brain disorders is unattainable. Valsartan …
Integrating Metabolomics, Histopathology, and Cardiac Marker Analysis to Assess Valsartan's Efficacy in Mitigating Dasatinib-Induced Cardiac Toxicity in Sprague …
K Alhazzani, H Mohammed, MM Algahtani… - Drug Design …, 2024 - Taylor & Francis
Background Dasatinib (DASA) is associated with cardiotoxic effects, posing risks to patients.
Valsartan (VAL) may offer protective benefits against these effects. This study evaluates the …
Valsartan (VAL) may offer protective benefits against these effects. This study evaluates the …
Candesartan and valsartan Zn (ii) complexes as inducing agents of reductive stress: mitochondrial dysfunction and apoptosis
VR Martínez, MV Aguirre, JS Todaro… - New Journal of …, 2021 - pubs.rsc.org
Cellular oxidative stress is considered an inducer of carcinogenesis but the association of
reactive oxygen species (ROS) with cancer is sometimes contradictory. The antihypertensive …
reactive oxygen species (ROS) with cancer is sometimes contradictory. The antihypertensive …