Unravelling the regulatory programs from single-cell multi-omics data has long been one of
the major challenges in genomics, especially in the current emerging single-cell field …

The HER2-positive patients occupy~ 30% of the total breast cancer patients globally where
no prevalent drugs are available to mitigate the frequent metastasis clinically except …

The origin and evolution of cell types has emerged as a key topic in evolutionary biology.
Driven by rapidly accumulating single-cell datasets, recent attempts to infer cell type …

Approximately 11% of human genes are transcribed by a bidirectional promoter (BDP),
defined as two genes with< 1 kb between their transcription start sites. Despite their …

Stem cells exist in vitro in a spectrum of interconvertible pluripotent states. Analyzing
hundreds of hiPSCs derived from different individuals, we show the proportions of these …

Bioenergy sorghum is a low‐input, drought‐resilient, deep‐rooting annual crop that has high
biomass yield potential enabling the sustainable production of biofuels, biopower, and …

Single-cell technologies promise to uncover how transcriptional programs orchestrate
complex processes during embryogenesis. Here, we apply a combination of single-cell …

Co‐expression of two or more genes at the single‐cell level is usually associated with
functional co‐regulation. While mRNA co‐expression—measured as the correlation in …

Skeletal muscle function and regenerative capacity decline during aging, yet factors driving
these changes are incompletely understood. Muscle regeneration requires temporally …

A lingering question in developmental biology has centered on how transcription factors with
widespread distribution in vertebrate embryos can perform tissue-specific functions. Here …