How nanoparticles open the paracellular route of biological barriers: mechanisms, applications, and prospects

J Wu, Z Zhu, W Liu, Y Zhang, Y Kang, J Liu, C Hu… - ACS …, 2022 - ACS Publications
Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …

Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease

C Chen, A Beloqui, Y Xu - Advanced drug delivery reviews, 2023 - Elsevier
Oral administration is the preferred route of administration based on the convenience for and
compliance of the patient. Oral nanomedicines have been developed to overcome the …

Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway

Y Mo, Y Zhang, Y Zhang, J Yuan, L Mo… - Journal of …, 2021 - Springer
Abstract Background Nickel nanoparticles (Nano-Ni) are increasingly used in industry and
biomedicine with the development of nanotechnology. However, the genotoxic and …

Polystyrene nanoplastics inhibit StAR expression by activating HIF-1α via ERK1/2 MAPK and AKT pathways in TM3 Leydig cells and testicular tissues of mice

A Sui, C Yao, Y Chen, Y Li, S Yu, J Qu, H Wei… - Food and Chemical …, 2023 - Elsevier
Abstract Microplastics (MPs) and nanoplastics (NPs) are widely found in water, food and air,
and have been found in human blood, lung and feces. Several studies in vivo have shown …

Nickel nanoparticles induce autophagy and apoptosis via HIF-1α/mTOR signaling in human bronchial epithelial cells

J Yuan, Y Mo, Y Zhang, Y Zhang, Q Zhang - Environmental Pollution, 2023 - Elsevier
With the rapid development of nanotechnology, the potential adverse health effects of
nanoparticles have been caught more attention and become global concerns. However, the …

Assessment of the cytotoxicity of nano gallium liquid metal droplets for biomedical applications

S Cheeseman, SJ Bryant, LZY Huang… - ACS Applied Nano …, 2022 - ACS Publications
Gallium-based liquid metals (LMs) have emerged as novel materials for biomedical
applications. Gallium (Ga) is considered significantly less toxic than other LMs, such as …

Dl‐3‐n‐butylphthalide promotes synaptic plasticity by activating the Akt/ERK signaling pathway and reduces the blood–brain barrier leakage by inhibiting the HIF‐1α …

P Che, J Zhang, M Yu, P Tang, Y Wang… - CNS neuroscience & …, 2023 - Wiley Online Library
Abstract Aims DL‐3‐n‐butylphthalide (NBP) exerts beneficial effects on global cognitive
functions, but the underlying molecular mechanisms are still poorly understood. The present …

MMP-3 activation is involved in copper oxide nanoparticle-induced epithelial-mesenchymal transition in human lung epithelial cells

Y Zhang, Y Mo, J Yuan, Y Zhang, L Mo, Q Zhang - Nanotoxicology, 2021 - Taylor & Francis
Abstract Copper oxide nanoparticles (Nano-CuO) are widely used in medical and industrial
fields and our daily necessities. However, the biosafety assessment of Nano-CuO is far …

Nanomaterials disrupting cell-cell junctions towards various diseases

S Xu, X Pang, X Zhang, Q Lv, M Zhang, J Wang, N Ni… - Nano Research, 2023 - Springer
As the continuous development of the industrial revolution, nanomaterials with excellent
characteristics have been widely applied in various fields, greatly increasing the probability …

Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors

S Chen, Y Su, M Zhang, Y Zhang, P Xiu, W Luo… - Journal of …, 2023 - Springer
Atherosclerosis is one of the most common types of cardiovascular disease and is driven by
lipid accumulation and chronic inflammation in the arteries, which leads to stenosis and …