There are presently more than 18 known aflatoxins most of which have been insufficiently
studied for their incidence, health-risk, and mechanisms of toxicity to allow effective …

Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and …

Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

Following critical evaluation of the available literature to date, The International Society of
Sports Nutrition (ISSN) position regarding caffeine intake is as follows: Supplementation with …

Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …

Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …

Cytochromes P450s (CYPs) constitute a superfamily of enzymes that catalyze the
metabolism of drugs and other substances. Endogenous substrates of CYPs include …

Induction of intestinal drug metabolizing enzymes can complicate the development of new
drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in …

The cytochrome P450 (CYP) enzymes are a diverse group of heme monooxygenases that,
through the course of their reaction cycle, can contribute to cellular reactive oxygen species …

There are 18 mammalian cytochrome P450 (CYP) families, which encode 57 genes in the
human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 …