Extracellular vesicles as therapeutic resources in the clinical environment

J Sanz-Ros, C Mas-Bargues, N Romero-García… - International journal of …, 2023 - mdpi.com
The native role of extracellular vesicles (EVs) in mediating the transfer of biomolecules
between cells has raised the possibility to use them as therapeutic vehicles. The …

Global trends of exosomes application in clinical trials: a scoping review

M Rahnama, M Heidari, Z Poursalehi… - Stem Cell Reviews and …, 2024 - Springer
Background Exosomes, nano-sized extracellular vesicles, have emerged as a promising
tool for the diagnosis and treatment of various intractable diseases, including chronic …

Extracellular vesicles: From bone development to regenerative orthopedics

OG Davies - Molecular Therapy, 2023 - cell.com
Regenerative medicine aims to promote the replacement of tissues lost to damage or
disease. While positive outcomes have been observed experimentally, challenges remain in …

Advances in platelet rich plasma-derived extracellular vesicles for regenerative medicine: A systematic-narrative review

E Anitua, M Troya, JM Falcon-Pérez… - International Journal of …, 2023 - mdpi.com
The use of platelet-rich plasma (PRP) has gained increasing interest in recent decades. The
platelet secretome contains a multitude of growth factors, cytokines, chemokines, and other …

Autologous platelet and extracellular vesicle-rich plasma as therapeutic fluid: a review

K Troha, D Vozel, M Arko, A Bedina Zavec… - International journal of …, 2023 - mdpi.com
The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has
been explored in many medical fields with the aim to benefit from its healing potential. In …

Biomimetic synthesis and optimization of extracellular vesicles for bone regeneration

X Song, L Xu, W Zhang - Journal of Controlled Release, 2023 - Elsevier
Critical-size bone defect repair is in high demand but is difficult to treat. Modern therapies,
such as autograft and cell-based treatments, face limitations, including potential …

Message in a bubble: the translational potential of extracellular vesicles

H Alqurashi, M Alsharief, ML Perciato… - The Journal of …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are small, membrane‐enclosed vesicles released by cells into
the extracellular milieu. They are found in all body fluids and contain a variety of functional …

Extracellular vesicles as human therapeutics: A scoping review of the literature

C Fusco, G De Rosa, I Spatocco… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are released by all cells and contribute to cell‐to‐cell
communication. The capacity of EVs to target specific cells and to efficiently deliver a …

Platelet-released factors: their role in viral disease and applications for extracellular vesicle (EV) therapy

B Ostermeier, N Soriano-Sarabia… - International journal of …, 2022 - mdpi.com
Platelets, which are small anuclear cell fragments, play important roles in thrombosis and
hemostasis, but also actively release factors that can both suppress and induce viral …

Extracellular vesicle contents as non-invasive biomarkers in ovarian malignancies

LA McAlarnen, P Gupta, R Singh, S Pradeep… - Molecular Therapy …, 2022 - cell.com
Ovarian cancer most commonly presents at an advanced stage where survival is
approximately 30% compared with> 80% if diagnosed and treated before disease spreads …