Malaria is one of the most devastating infectious diseases of humans. It is problematic
clinically and economically as it prevails in poorer countries and regions, strongly hindering …

Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Abstract Background In Uganda, artemether-lumefantrine is recommended for malaria
treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug …

Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …

Antimalarial chemotherapy, globally reliant on artemisinin-based combination therapies
(ACTs), is threatened by the spread of drug resistance in Plasmodium falciparum parasites …

Plasmodium falciparum resistance to chloroquine and sulphadoxine–pyrimethamine has led
to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of …

Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …

Abstract Chloroquine (CQ) and Hydroxychloroquine (HCQ) have been commonly used for
the treatment and prevention of malaria, and the treatment of autoimmune diseases for …

Strategies to counteract or prevent emerging drug resistance are crucial for the design of
next-generation antimalarials. In the past, resistant parasites were generally identified …