Microgravity effects on the human brain and behavior: Dysfunction and adaptive plasticity

KE Hupfeld, HR McGregor, PA Reuter-Lorenz… - Neuroscience & …, 2021 - Elsevier
Emerging plans for travel to Mars and other deep space destinations make it critical for us to
understand how spaceflight affects the human brain and behavior. Research over the past …

Neurophysiological adaptations to spaceflight and simulated microgravity

AB Stella, M Ajčević, G Furlanis, P Manganotti - Clinical Neurophysiology, 2021 - Elsevier
Abstract Changes in physiological functions after spaceflight and simulated spaceflight
involve several mechanisms. Microgravity is one of them and it can be partially reproduced …

[HTML][HTML] Alterations of functional brain connectivity after long-duration spaceflight as revealed by fMRI

E Pechenkova, I Nosikova, A Rumshiskaya… - Frontiers in …, 2019 - frontiersin.org
The present study reports alterations of task-based functional brain connectivity in a group of
11 cosmonauts after a long-duration spaceflight, compared to a healthy control group not …

Brain and behavioral evidence for reweighting of vestibular inputs with long-duration spaceflight

KE Hupfeld, HR McGregor, V Koppelmans… - Cerebral …, 2022 - academic.oup.com
Microgravity alters vestibular signaling. In-flight adaptation to altered vestibular afferents is
reflected in post-spaceflight aftereffects, evidenced by declines in vestibularly mediated …

[HTML][HTML] Impact of different ground-based microgravity models on human sensorimotor system

A Saveko, M Bekreneva, I Ponomarev… - Frontiers in …, 2023 - frontiersin.org
This review includes current and updated information about various ground-based
microgravity models and their impact on the human sensorimotor system. All known models …

[HTML][HTML] Brain connectivity and behavioral changes in a spaceflight analog environment with elevated CO2

HR McGregor, JK Lee, ER Mulder, YE De Dios… - Neuroimage, 2021 - Elsevier
Astronauts are exposed to microgravity and elevated CO 2 levels onboard the International
Space Station. Little is known about how microgravity and elevated CO 2 combine to affect …

[HTML][HTML] The effects of 30 minutes of artificial gravity on cognitive and sensorimotor performance in a spaceflight analog environment

GD Tays, HR McGregor, JK Lee, N Beltran… - Frontiers in Neural …, 2022 - frontiersin.org
The altered vestibular signaling and somatosensory unloading of microgravity result in
sensory reweighting and adaptation to conflicting sensory inputs. Aftereffects of these …

[HTML][HTML] Neural working memory changes during a spaceflight analog with elevated carbon dioxide: a pilot study

AP Salazar, KE Hupfeld, JK Lee, NE Beltran… - Frontiers in Systems …, 2020 - frontiersin.org
Spaceflight missions to the International Space Station (ISS) expose astronauts to
microgravity, radiation, isolation, and elevated carbon dioxide (CO2), among other factors …

[HTML][HTML] Neural Correlates of Vestibular Processing During a Spaceflight Analog With Elevated Carbon Dioxide (CO2): A Pilot Study

KE Hupfeld, JK Lee, NE Gadd, IS Kofman… - Frontiers in Systems …, 2020 - frontiersin.org
Astronauts return to Earth from spaceflight missions with impaired mobility and balance;
recovery can last weeks postflight. This is due in large part to the altered vestibular signaling …

Effects of spaceflight stressors on brain volume, microstructure, and intracranial fluid distribution

JK Lee, V Koppelmans, O Pasternak… - Cerebral Cortex …, 2021 - academic.oup.com
Astronauts are exposed to elevated CO2 levels onboard the International Space Station.
Here, we investigated structural brain changes in 11 participants following 30-days of head …