Antagonism of protein–protein interactions (PPIs) with small molecules is becoming more
feasible as a therapeutic approach. Successful PPI inhibitors tend to target proteins …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Background: Immune responses following vaccination against COVID-19 with different
vaccines and the waning of immunity vary within the population. Genetic host factors are …

Understanding the genetic architecture of athletic performance is an important step in the
development of methods for talent identification in sport. Research concerned with …

Hypertension is a frequent, chronic, age-related disorder, which often entails debilitating
cardiovascular and renal complications. Blood pressure is usually noted in combination with …

Human Evolutionary Genetics is a groundbreaking text which for the first time brings
together molecular genetics and genomics to the study of the origins and movements of …

Background In view of consistently high cardiovascular morbidity and mortality rates,
international efforts are aimed at developing tools for more precise risk prediction to allow …

This systematic review summarizes pharmacogenetic studies on antidepressant response
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta …

Receptors on cell membranes sense a variety of signals such as neurotransmitters,
hormones, and light. The vast majority of such receptors are coupled to G proteins, which …

Ethnicity is an important demographic variable contributing to interindividual variability in
drug metabolism and response. In this rapidly expanding research area many genetic …