Pathophysiological mechanisms implicated in postpartum depression

JL Payne, J Maguire - Frontiers in neuroendocrinology, 2019 - Elsevier
This review aims to summarize the diverse proposed pathophysiological mechanisms
contributing to postpartum depression, highlighting both clinical and basic science research …

The neurobiology of postpartum anxiety and depression

JL Pawluski, JS Lonstein, AS Fleming - Trends in neurosciences, 2017 - cell.com
Ten to twenty percent of postpartum women experience anxiety or depressive disorders,
which can have detrimental effects on the mother, child, and family. Little is known about the …

Epigenetics in depression and gut-brain axis: A molecular crosstalk

N Begum, A Mandhare, KP Tryphena… - Frontiers in Aging …, 2022 - frontiersin.org
Gut-brain axis is a dynamic, complex, and bidirectional communication network between the
gut and brain. Changes in the microbiota-gut-brain axis are responsible for developing …

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

M Yuan, B Yang, G Rothschild, JJ Mann… - Signal transduction and …, 2023 - nature.com
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Postpartum depression: Current status and possible identification using biomarkers

Y Yu, HF Liang, J Chen, ZB Li, YS Han… - Frontiers in …, 2021 - frontiersin.org
Postpartum depression (PPD) is a serious health issue that can affect about 15% of the
female population within after giving birth. It often conveys significant negative …

Developmental programming of oxytocin through variation in early-life stress: Four meta-analyses and a theoretical reinterpretation

BJ Ellis, AJ Horn, CS Carter, MH van IJzendoorn… - Clinical Psychology …, 2021 - Elsevier
Despite evidence supporting a role for oxytocin (OT) in regulating social behavior,
surprisingly little is known about how this neuropeptide is calibrated during development …

A review of DNA methylation in depression

D Chen, L Meng, F Pei, Y Zheng, J Leng - Journal of Clinical Neuroscience, 2017 - Elsevier
As one of the most common psychiatric disorders, depression has been a major public
health problem. Growing evidence suggests that epigenetic modification is essential in …

The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review

C Maud, J Ryan, JE McIntosh, CA Olsson - BMC psychiatry, 2018 - Springer
Abstract Background The neuropeptide Oxytocin (OXT) plays a central role in birthing,
mother-infant bonding and a broad range of related social behaviours in mammals. More …

Perinatal major depression biomarkers: a systematic review

M Serati, M Redaelli, M Buoli, AC Altamura - Journal of affective disorders, 2016 - Elsevier
Postpartum depression, now termed perinatal depression by the DSM-5, is a clinically
relevant disorder reaching 15% of incidence. Although it is quite frequent and associated …

[HTML][HTML] Early nurture epigenetically tunes the oxytocin receptor

AM Perkeybile, CS Carter, KL Wroblewski… - …, 2019 - Elsevier
Mammalian sociality is regulated in part by the neuropeptide oxytocin. In prairie voles, subtle
variation in early life experience changes oxytocin receptor-mediated social behaviors. We …