Mycobacteria are the causative organisms for diseases such as tuberculosis (TB), leprosy,
Buruli ulcer, and pulmonary nontuberculous mycobacterial disease, to name the most …

Background Targeted next-generation sequencing (NGS) can rapidly and simultaneously
detect mutations associated with resistance to tuberculosis drugs across multiple gene …

Amplicon-based Next Generation Sequencing (NGS) is an emerging method for
Mycobacterium tuberculosis drug susceptibility testing (DST) but has not been well …

Background Tuberculosis is one of the deadliest disease caused by Mycobacterium
tuberculosis. Its treatment still becomes a burden for many countries including Indonesia …

The emergence of drug-resistant tuberculosis is a significant global health issue. The
presence of heteroresistant Mycobacterium tuberculosis is critical to developing fully drug …

Pyrazinamide (PZA) is an essential first-line tuberculosis drug for its unique mechanism of
action active against multidrug-resistant-TB (MDR-TB). Thus, the aim of updated meta …

In an effort to discover the mechanism of resistance offered by Mycobacterium tuberculosis
(Mtb) toward the pyrazinamide (PZA) drug, an extensive molecular dynamics strategy was …

Pyrazinamide (PZA) has remained a keystone of tuberculosis (TB) therapy, and it possesses
high imperative sterilizing action that can facilitate reduction in the present chemotherapy …

Abstract Background Drug resistance in Mycobacterium tuberculosis (MTB) is a major health
issue worldwide. Recently, next-generation sequencing (NGS) technology has begun to be …

Pyrazinamide (PZA) is a standard component of first-line treatment regimens for
Mycobacterium tuberculosis and is included in treatment regimens for drug-resistant M …