As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

Mitochondrial dysfunction is a hallmark of many diseases. The retrograde signaling initiated
by dysfunctional mitochondria can bring about global changes in gene expression that alters …

Summary The Cdc48 ATPase and its cofactors Ufd1/Npl4 (UN) extract polyubiquitinated
proteins from membranes or macromolecular complexes, but how they perform these …

Age‐related changes in mitochondria are associated with decline in mitochondrial function.
With advanced age, mitochondrial DNA volume, integrity and functionality decrease due to …

Aging is characterized by a progressive loss of muscle mass and muscle strength. Declines
in skeletal muscle mitochondria are thought to play a primary role in this process …

Yeasts, such as Saccharomyces cerevisiae, have long served as useful models for the study
of oxidative stress, an event associated with cell death and severe human pathologies. This …

Both melatonin and proteasome inhibitors upregulate antioxidant enzymes including
superoxide dismutase (SOD), glutathione peroxidase (GP), hemoxygenase 1 (HO-1), and …

Protein homeostasis deficiencies underlie various cancers and neurodegenerative
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …

Chloroplasts are the site of numerous biochemical reactions including photosynthesis, but
they also produce reactive oxygen species (ROS) that negatively affect chloroplast integrity …

Mitochondria are pivotal organelles in eukaryotic cells. The complex proteome of
mitochondria comprises proteins that are encoded by nuclear and mitochondrial genomes …