Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Epigenome reprogramming after fertilization enables transcriptionally quiescent maternal
and paternal chromatin to acquire a permissive state for subsequent zygotic genome …

Patients with high ALDH1A3-expressing glioblastoma (ALDH1A3 hi GBM) show limited
benefit from postoperative chemoradiotherapy. Understanding the mechanisms underlying …

Chromatin modifications shape the epigenome and are essential for gene expression
reprogramming during plant development and adaptation to the changing environment …

Acetyl-CoA utilized by histone acetyltransferases (HAT) for chromatin modification is mainly
generated by ATP-citrate lyase (ACL) from glucose sources. How ACL locally establishes …

Chromatin plays a crucial role in genome compaction and is fundamental for regulating
multiple nuclear processes. Nucleosomes, the basic building blocks of chromatin, are …

The urea cycle is frequently rewired in cancer cells to meet the metabolic demands of
cancer. Elucidation of the underlying mechanism by which oncogenic signaling mediates …

Acetyl-coenzyme A (acetyl-CoA), an essential metabolite, not only takes part in numerous
intracellular metabolic processes, powers the tricarboxylic acid cycle, serves as a key hub …

Histone acetylation is highly conserved across eukaryotes and has been linked to gene
activation since its discovery nearly 60 years ago. Over the past decades, histone …