The Glucose-Regulated Protein78 (GRP78) in the unfolded protein response (UPR) pathway: a potential therapeutic target for breast cancer

MM Sadeghipour, SA Torabizadeh… - Anti-Cancer Agents in …, 2023 - ingentaconnect.com
Amongst all types of cancers, breast cancer is recognized as the most common cancer and a
principal cause of morbidity and mortality in women. Endoplasmic reticulum (ER) stress …

Primed for death: prognostic role of BH3--only proteins in breast cancer therapy: a systematic and meta-analysis review

TAESA Taha, S Omar, NK Abdelsattar… - Translational Medicine …, 2024 - Springer
Background Breast cancer (BC) is the primary cause of cancer-related deaths among
women. BH3 only proteins expression profile in BC has been linked to chemotherapy and …

[HTML][HTML] The pro-apoptotic paradox: the BH3-only protein Bcl-2 interacting killer (Bik) is prognostic for unfavorable outcomes in breast cancer

V Pandya, D Glubrecht, L Vos, J Hanson, S Damaraju… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Breast cancer is the leading cause of cancer-associated deaths in women worldwide.
Clinical biomarkers give information on disease progression and identify relevant biological …

Correlation of the protein expression of GRP78 and BIK/NBK with prognostic markers in patients with breast cancer and neoadjuvant chemotherapy

E López-Muñoz, M Corres-Molina… - Journal of Obstetrics …, 2020 - Taylor & Francis
The objective of this study was to determine the frequency of expression of GRP78 and
BIK/NBK proteins, as well as to evaluate their correlation with prognostic factors for clinical …

Small activating RNA restores the activity of the tumor suppressor HIC-1 on breast cancer

F Zhao, S Pan, Y Gu, S Guo, Q Dai, Y Yu, W Zhang - PLoS One, 2014 - journals.plos.org
HIC-1 is a gene that is hypermethylated in cancer, and commonly downregulated in human
breast cancer. However, the precise mechanisms and molecular pathways regulated by HIC …

[HTML][HTML] A novel messenger RNA signature as a prognostic biomarker for predicting relapse in pancreatic ductal adenocarcinoma

G Shi, J Zhang, Z Lu, D Liu, Y Wu, P Wu, J Yin… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) death rate and recurrence rate have remained
obstinately high. Current methods can not satisfy the need of predicting cancer relapse …

[HTML][HTML] BIK and GRP78 protein expression as possible markers of response to preoperative chemotherapy and survival in breast cancer

CDMT de Jesús, MGA Jaim, VVC Karina… - Taiwanese Journal of …, 2021 - Elsevier
Objective BIK and GRP78 have shown differential expression profiles in breast cancer (BC)
tissue, in addition to its important participation in the pathophysiology of cancer. The …

Investigation of BCL-2 interacting killer (BIK) as a breast cancer biomarker and its role in failed apoptosis

VK Pandya - 2019 - era.library.ualberta.ca
Breast cancer is the number one cause of cancer-associated deaths in women worldwide. It
can be broadly classified into estrogen receptor (ER) positive or-negative subtypes which …

Participación de la proteína BIK en los procesos apoptóticos

JC Gutiérrez-Santana, G García-Casillas… - Revista del Hospital …, 2014 - medigraphic.com
Cell death (apoptosis) is a process relevant in the development and differentiation of
multicellular organism and its alterations raise pathological conditions. Apoptosis is tightly …