Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

For many years, the ubiquitin-26S proteasome degradation pathway was considered the
primary route for proteasomal degradation. However, it is now becoming clear that proteins …

Regulated cellular proteolysis is mediated largely by the ubiquitin–proteasome system
(UPS). It is a highly specific process that is time-(eg cell cycle), compartment-(eg nucleus or …

The inhibitory IκB proteins have been discovered as fundamental regulators of the inducible
transcription factor nuclear factor‐κB (NF‐κB). As a generally excepted model, stimulus …

IκB proteins are known as the regulators of NF‐κB activity. They bind tightly to NF‐κB dimers,
until stimulus‐responsive N‐terminal phosphorylation by IKK triggers their ubiquitination and …

Background and aims Inflammatory bowel disease (IBD), comprising Crohn´ s disease and
ulcerative colitis, is characterised by chronic relapsing inflammation of the gut. Increased …

The degradation of the majority of cellular proteins is mediated by the proteasomes.
Ubiquitin‐dependent proteasomal protein degradation is executed by a number of enzymes …

In eukaryotes, thousands of genes have to be organized and expressed in the cell nucleus.
Conformational and kinetic instability of nuclear structure and components appear to enable …

The 20S proteasome is a multicatalytic proteinase catalysing the degradation of the majority
of intracellular proteins. Thereby it is involved in almost all basic cellular processes, which is …

Enhanced NF-κB activity is involved in the pathology of both forms of inflammatory bowel
disease (IBD), Crohn disease (CD) and ulcerative colitis (UC). Here we analyzed the …