Citrus flavonoids as promising phytochemicals targeting diabetes and related complications: A systematic review of in vitro and in vivo studies

GR Gandhi, ABS Vasconcelos, DT Wu, HB Li… - Nutrients, 2020 - mdpi.com
The consumption of plant-based food is important for health promotion, especially
concerning the prevention and management of chronic diseases. Flavonoids are the main …

Naringenin and naringin in cardiovascular disease prevention: A preclinical review

RH Moghaddam, Z Samimi, SZ Moradi, PJ Little… - European Journal of …, 2020 - Elsevier
Cardiovascular disease is an important cause for morbidity and mortality worldwide.
Flavonoids, such as naringin, and naringenin are important natural phytochemicals in the …

Naringin ameliorates 5-fluorouracil induced cardiotoxicity: An insight into its modulatory impact on oxidative stress, inflammatory and apoptotic parameters

Y Gui, AC Famurewa, OJ Olatunji - Tissue and Cell, 2023 - Elsevier
fluorouracil (5-FU) is an efficacious fluoropyrimidine antimetabolite anticancer drug,
however, its clinical utility is constrained due to side effect toxicity on delicate organs …

The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases

JA Adetunji, KD Fasae, AI Awe, OK Paimo… - Heliyon, 2023 - cell.com
The endothelial cells (ECs) make up the inner lining of blood vessels, acting as a barrier
separating the blood and the tissues in several organs. ECs maintain endothelium integrity …

New perspectives in the pharmacological potential of naringin in medicine

MA Rivoira, V Rodriguez, G Talamoni… - Current medicinal …, 2021 - ingentaconnect.com
Background: Naringin (NAR) is a flavonoid enriched in several medicinal plants and fruits.
An increasing interest in this molecule has emerged because it has the potential to …

High fructose intake and the route towards cardiometabolic diseases

D de Farias Lelis, JMO Andrade, CCP Almenara… - Life Sciences, 2020 - Elsevier
It is known that dietary habits have a strong influence on body metabolism. In the last
decades, the dietary habits have changed worldwide, and the consumption of fructose …

Naringin attenuates fructose-induced NAFLD progression in rats through reducing endogenous triglyceride synthesis and activating the Nrf2/HO-1 pathway

S Pengnet, P Sumarithum, N Phongnu… - Frontiers in …, 2022 - frontiersin.org
Background: Excessive fructose consumption causes hepatic lipid accumulation via
increased triglyceride (TG) synthesis, leading to the development and progression of non …

Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of …

SA Kehinde, TP Fatokun, AT Olajide, SM Praveena… - Scientific Reports, 2024 - nature.com
The widespread presence of microplastics in the environment has raised significant
concerns regarding their potential impact on human and animal health. Among various …

The effects of citrus flavonoids supplementation on endothelial function: A systematic review and dose–response meta‐analysis of randomized clinical trials

F Jalili, S Moradi, S Talebi, S Mehrabani… - Phytotherapy …, 2024 - Wiley Online Library
The present systematic review and dose–response meta‐analysis was conducted to
synthesize existing data from randomized clinical trials (RCTs) concerning the impact of …

Short‐term isocaloric intake of a fructose‐but not glucose‐rich diet affects bacterial endotoxin concentrations and markers of metabolic health in normal weight healthy …

A Nier, A Brandt, D Rajcic, T Bruns… - Molecular nutrition & …, 2019 - Wiley Online Library
Scope Dietary pattern and impairments of intestinal barrier function are discussed to be
critical in the development of metabolic impairments. Here, it is determined if an isocaloric …